Testicular receptor 4

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesNR2C2, TAK1, TR4, Testicular receptor 4, nuclear receptor subfamily 2 group C member 2

External IDsOMIM: 601426; MGI: 1352466; HomoloGene: 2475; GeneCards: NR2C2; OMA:NR2C2 - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts NR2C2, Available structures ...

NR2C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P0U
Identifiers
Aliases	NR2C2, TAK1, TR4, Testicular receptor 4, nuclear receptor subfamily 2 group C member 2
External IDs	OMIM: 601426; MGI: 1352466; HomoloGene: 2475; GeneCards: NR2C2; OMA:NR2C2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 14,947,583 bp[1] End 15,053,600 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 92,068,371 bp[2] End 92,151,275 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve skin of thigh tibia skin of hip epithelium of colon jejunal mucosa superficial temporal artery epithelium of nasopharynx ganglionic eminence parietal pleura Top expressed in Rostral migratory stream spermatocyte dentate gyrus of hippocampal formation granule cell genital tubercle ventromedial nucleus lateral septal nucleus lumbar subsegment of spinal cord supraoptic nucleus ventricular zone superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity transcription coactivator activity zinc ion binding metal ion binding steroid hormone receptor activity protein binding protein heterodimerization activity RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity Cellular component nucleoplasm nucleus Biological process cell differentiation regulation of transcription, DNA-templated nervous system development transcription, DNA-templated spermatogenesis transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7182 22026 Ensembl ENSG00000177463 ENSMUSG00000005893 UniProt P49116 P49117 RefSeq (mRNA) NM_001291694 NM_003298 NM_011630 NM_001347342 RefSeq (protein) NP_001278623 NP_003289 NP_001334271 NP_035760 Location (UCSC) Chr 3: 14.95 – 15.05 Mb Chr 6: 92.07 – 92.15 Mb PubMed search [3] [4]
Wikidata
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The testicular receptor 4 is a member of the nuclear receptor family of transcription factors. Though currently considered an orphan receptor, it nevertheless has an important role as a core DNA binding component of the so called DRED complex (direct repeat erythroid determinant). This complex is formed out of TR4, testicular receptor 2, DNMT1, and KDM1A, and functions as a gene repressor the regulates the expression of red blood cell globin. In particular, it contributes to the transition from fetal to adult pattern expression.^[8]