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Transient neonatal diabetes

Medical condition From Wikipedia, the free encyclopedia

Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

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Transient neonatal diabetes
Transient neonatal diabetes mellitus is inherited in an autosomal dominant manner[1]
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Types

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Type OMIM Gene Locus Description
TNDM1 601410 ZFP57, PLAGL1 6p22.1, 6q24.2
TNDM2 610374 ABCC8 11p15.1 Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.[2]
TNDM3 610582 KCNJ11 11p15.1
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Cause

This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).[citation needed]

The form on chromosome 6 can involve imprinting.[3][4]

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