UBIAD1

UbiA prenyltransferase domain-containing protein 1 (UBIAD1) also known as transitional epithelial response protein 1 (TERE1) is a protein that in humans is encoded by the UBIAD1 gene.^[5][6][7]

AliasesUBIAD1, SCCD, TERE1, UbiA prenyltransferase domain containing 1

External IDsOMIM: 611632; MGI: 1918957; HomoloGene: 8336; GeneCards: UBIAD1; OMA:UBIAD1 - orthologs

Chr.Chromosome 1 (human)^[1]

End11,296,049 bp^[1]

Quick facts Identifiers, Aliases ...

UBIAD1
Identifiers
Aliases	UBIAD1, SCCD, TERE1, UbiA prenyltransferase domain containing 1
External IDs	OMIM: 611632; MGI: 1918957; HomoloGene: 8336; GeneCards: UBIAD1; OMA:UBIAD1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,273,198 bp[1] End 11,296,049 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 148,518,952 bp[2] End 148,529,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh gonad secondary oocyte skin of thigh ganglionic eminence islet of Langerhans nipple granulocyte ventricular zone Top expressed in zygote proximal tubule right kidney secondary oocyte primary oocyte human kidney interventricular septum yolk sac muscle of thigh Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity antioxidant activity protein binding prenyltransferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups Cellular component cytoplasm integral component of membrane integral component of Golgi membrane Golgi apparatus endoplasmic reticulum membrane membrane mitochondrial membranes Golgi membrane endoplasmic reticulum mitochondrion nucleus Biological process menaquinone biosynthetic process ubiquinone biosynthetic process vitamin K biosynthetic process vitamin K metabolic process cellular oxidant detoxification ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29914 71707 Ensembl ENSG00000120942 ENSMUSG00000047719 UniProt Q9Y5Z9 Q9DC60 RefSeq (mRNA) NM_013319 NM_001330349 NM_001330350 NM_027873 RefSeq (protein) NP_001317278 NP_001317279 NP_037451 NP_082149 Location (UCSC) Chr 1: 11.27 – 11.3 Mb Chr 4: 148.52 – 148.53 Mb PubMed search [3] [4]
Wikidata
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The enzyme is named for its canonical role in ubiquinone production, catalyzing reaction EC 2.5.1.39; it thus has a role in oxidative stress pathways.^[8]

Recent evidence suggests that UBIAD1 has enzymatic activity in the vitamin K pathway, converting menadione to MK-4.^[9][10] This translates to a role in blood vessel development in zebrafish.^[11]