User talk:Gerriet42

We seem to be reverting each other's work, so maybe it would make sense to talk and discuss what we can agree on and agree to disagree. Benzophenone is not a component of sunscreens so I removed FEBS Lett ref from there, its irrelevant - at least in my view. More significant is the Padimate O article. I am trying to do several things with my edits, two of which sould be fairly okay with you: upgrade English, use wiki-format (links, capitalizing subheaders). The place where we seem to differ is the degree to which you want to help the reader extrapolate from the photocarcinogenicity of Micher's ketone to the conclusion that Padimate O is causing melanoma. I feel that you are speculating and over-reaching (but surely you dont see it that way!). So let's talk for a while (we can discuss it on this site, if that's okay) and see if we can iron out some consensus. These reversion cycles really set editors on edge, beyond reason. Cheers,--Smokefoot (talk) 19:54, 10 May 2008 (UTC)

Hi, It was not written that benzophenone was an ingredient in sunscreens. However it was written that derivatives of benzophenone are used as sunscreen ingredients. I would like to keep this in the article, because it is a point that had been criticized repeatedly by researchers. ^[1][2][3]

Are you aware, that most epidemiological studies show an increased melanoma risk for sunscreen users compared to non users? See^{[4][5][6][7][8]}

You should read the Kerry Hanson paper. They measure the concentration of ROS inside the skin and they compare sunscreen treated with untreated skin. They see, that after the sunscreen had time to penetrate into the skin the concentration of ROS is substantially higher than in the untreated skin.^[9]

About Padimate O: I think that Knowland and McKenzie say exactly what I wrote: These findings are an indication for a photocarcinogenic effect of padimate O. These findings are in agreement with those from Xu et al. They have shown that human melanocytes suffer more DNA damage from UV-illumination when in contact with padimate O then they do without this sunscreen ingredient.^[10] Even at a very low concentration of 25 μmol/l the combination of padimate O with solar UV exposure can selectively damage this type of human skin cells. This concentration of the sunscreen ingredient is likely to be achieved in the skin.^[10] Gerriet42 (talk) 06:09, 13 May 2008 (UTC)

thanks for the note. The thing that some of us are leery about is turning these articles into advice columns, since advice is specifically discouraged in this encyclopedia and anything verging on original research. Benzophenone is a very common building block and is, formally, a structural component of many hundreds of species, some good and some bad. While I can see your point on the wording of the padimate-O, I question the value of adding every mention of any skeletal connection between all benzophenone species and the parent molecule. The article on benzophenone would be unwieldy and the core information (what is it and what are is main properties) would be diluted out. Why not connect sunscreens to benzene too, since sunscreens are benzene derivatives? So you can see what I mean, hopefully. More later, off to work. --Smokefoot (talk)