Y box binding protein 1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[5] YBX1 is an RNA binding protein[6] that stabilises messenger RNAs modified with N6-methyladenosine.[7]
Clinical significance
YBX1 is a potential drug target in cancer therapy.[8] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[8] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.
DNA repair
The mitochondria of human cells possess a repair pathway for DNA base pair mismatches that is distinct from the DNA mismatch repair pathway of the nucleus.[9] This mitochondrial pathway includes participation of Y box binding protein 1 (designated YB-1 or YBX1), that likely acts in the mismatch binding and recognition steps of mismatch repair.[9]