NFKB1

Este gen codifica una proteína de 105 kDa que puede sufrir procesamiento co-traduccional el proteasoma 26S para generar una proteína de 50 kDa. La proteína de 105 kDa es un inhibidor Rel específico de transcripción y la de 50 kDa es una subunidad de unión a ADN del complejo proteico NF-κB. NF-κB es un factor de transcripción que es activado por diversos estímulos intra- y extracelulares, tales como citoquinas, radicales libres de oxígeno, radiación UV y productos bacterianos y virales. El complejo NF-κB activado es traslocado al núcleo celular y estimula la expresión de genes implicados en una amplia variedad de procesos biológicos; en torno a 200 genes conocidos son dianas de NF-κB en varios tipos de células diferentes, bajo condiciones específicas. Una activación inapropiada de NF-κB se ha asociado con un cierto número de enfermedades inflamatorias, mientras que una inhibición persistente de NF-κB conduce a un desarrollo incorrecto de células del sistema inmune o un retraso en el crecimiento celular.^[2]

Significación clínica

Existen 736 enfermedades descritas que coinciden con NFKB1^[3]

Interacciones

La proteína NFKB1 ha demostrado ser capaz de interaccionar con:

NFKBIE^[4]
IKK2^[5]^[6]
MAP3K7IP2^[7]
STAT6^[8]
ITGB3BP^[9]
IκBα^[10]^[11]
NFKB2^[12]
RELA^[12]^[13]
RELB^[12]
TSC22D3^[14]
NOTCH1^[15]^[16]
HDAC1^[17]
LYL1^[18]
BCL3^[19]^[20]^[6]
STAT3^[21]
MAP3K8^[22]^[12]
MEN1^[23]
NCOA1^[24]^[25]
HMGA2^[26]

Referencias

[1]
Meyer R, Hatada EN, Hohmann HP, Haiker M, Bartsch C, Rothlisberger U, Lahm HW, Schlaeger EJ, van Loon AP, Scheidereit C (Mar de 1991). «Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha». Proc Natl Acad Sci U S A 88 (3): 966-70. PMC 50935. PMID 1992489.
[2]
«Entrez Gene: NF-κB nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)».
[3]
«MalaCards». Consultado el 17 de febrero de 2026.
[4]
Li, Z; Nabel G J (Oct. de 1997). «A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription». Mol. Cell. Biol. (UNITED STATES) 17 (10): 6184-90. ISSN 0270-7306. PMID 9315679.
[5]
Heissmeyer, V; Krappmann D, Hatada E N, Scheidereit C (Feb. de 2001). «Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha». Mol. Cell. Biol. (United States) 21 (4): 1024-35. ISSN 0270-7306. PMID 11158290. doi:10.1128/MCB.21.4.1024-1035.2001.
[6]
Heissmeyer, V; Krappmann D, Wulczyn F G, Scheidereit C (Sep. de 1999). «NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes». EMBO J. (ENGLAND) 18 (17): 4766-78. ISSN 0261-4189. PMID 10469655. doi:10.1093/emboj/18.17.4766.
[7]
Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. de 2002). «Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein». Cell (United States) 110 (1): 55-67. ISSN 0092-8674. PMID 12150997.
[8]
Shen, C H; Stavnezer J (Jun. de 1998). «Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription». Mol. Cell. Biol. (UNITED STATES) 18 (6): 3395-404. ISSN 0270-7306. PMID 9584180.
[9]
Besta, Felicitas; Massberg Steffen, Brand Korbinian, Müller Elke, Page Sharon, Grüner Sabine, Lorenz Michael, Sadoul Karin, Kolanus Waldemar, Lengyel Ernst, Gawaz Meinrad (Oct. de 2002). «Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor». J. Cell. Sci. (England) 115 (Pt 20): 3879-88. ISSN 0021-9533. PMID 12244126.
[10]
Hay, D C; Kemp G D, Dargemont C, Hay R T (mayo. de 2001). «Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription». Mol. Cell. Biol. (United States) 21 (10): 3482-90. ISSN 0270-7306. PMID 11313474. doi:10.1128/MCB.21.10.3482-3490.2001.
[11]
Malek, S; Huxford T; Ghosh G (Sep. de 1998). «Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB». J. Biol. Chem. (UNITED STATES) 273 (39): 25427-35. ISSN 0021-9258. PMID 9738011.
[12]
Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. de 2004). «A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway». Nat. Cell Biol. (England) 6 (2): 97-105. ISSN 1465-7392. PMID 14755267. doi:10.1038/ncb1086.
[13]
Palvimo, J J; Reinikainen P, Ikonen T, Kallio P J, Moilanen A, Jänne O A (Sep. de 1996). «Mutual transcriptional interference between RelA and androgen receptor». J. Biol. Chem. (UNITED STATES) 271 (39): 24151-6. ISSN 0021-9258. PMID 8798655.
[14]
Ayroldi, E; Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug. de 2001). «Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB». Blood (United States) 98 (3): 743-53. ISSN 0006-4971. PMID 11468175.
[15]
Guan, E; Wang J, Laborda J, Norcross M, Baeuerle P A, Hoffman T (mayo. de 1996). «T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells». J. Exp. Med. (UNITED STATES) 183 (5): 2025-32. ISSN 0022-1007. PMID 8642313.
[16]
Wang, J; Shelly L, Miele L, Boykins R, Norcross M A, Guan E (Jul. de 2001). «Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain». J. Immunol. (United States) 167 (1): 289-95. ISSN 0022-1767. PMID 11418662.
[17]
Zhong, Haihong; May Michael J, Jimi Eijiro, Ghosh Sankar (Mar. de 2002). «The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1». Mol. Cell (United States) 9 (3): 625-36. ISSN 1097-2765. PMID 11931769.
[18]
Ferrier, R; Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (Jan. de 1999). «Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105». Oncogene (ENGLAND) 18 (4): 995-1005. ISSN 0950-9232. PMID 10023675. doi:10.1038/sj.onc.1202374.
[19]
Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec. de 2003). «Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma». Cancer Res. (United States) 63 (23): 8293-301. ISSN 0008-5472. PMID 14678988.
[20]
Naumann, M; Wulczyn F G, Scheidereit C (Jan. de 1993). «The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B». EMBO J. (ENGLAND) 12 (1): 213-22. ISSN 0261-4189. PMID 8428580.
[21]
Yu, Zhiyuan; Zhang Wenzheng, Kone Bruce C (Oct. de 2002). «Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB». Biochem. J. (England) 367 (Pt 1): 97-105. ISSN 0264-6021. PMID 12057007. doi:10.1042/BJ20020588.
[22]
Belich, M P; Salmerón A, Johnston L H, Ley S C (Jan. de 1999). «TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105». Nature (ENGLAND) 397 (6717): 363-8. ISSN 0028-0836. PMID 9950430. doi:10.1038/16946.
[23]
Heppner, C; Bilimoria K Y, Agarwal S K, Kester M, Whitty L J, Guru S C, Chandrasekharappa S C, Collins F S, Spiegel A M, Marx S J, Burns A L (Aug. de 2001). «The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation». Oncogene (England) 20 (36): 4917-25. ISSN 0950-9232. PMID 11526476. doi:10.1038/sj.onc.1204529.
[24]
Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. de 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6): 915-25. ISSN 0888-8809. PMID 10847592.
[25]
Na, S Y; Lee S K, Han S J, Choi H S, Im S Y, Lee J W (mayo. de 1998). «Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations». J. Biol. Chem. (UNITED STATES) 273 (18): 10831-4. ISSN 0021-9258. PMID 9556555.
[26]
Noro, Barbara; Licheri Barbara, Sgarra Riccardo, Rustighi Alessandra, Tessari Michela A, Chau Kai-Yin, Ono Santa Jeremy, Giancotti Vincenzo, Manfioletti Guidalberto (Apr. de 2003). «Molecular dissection of the architectural transcription factor HMGA2». Biochemistry (United States) 42 (15): 4569-77. ISSN 0006-2960. PMID 12693954. doi:10.1021/bi026605k.

Significación clínica

Interacciones

Referencias

Enlaces externos

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