YWHAB

Este gen codifica una proteína perteneciente a la familia de proteínas 14-3-3, cuyos miembros median en la transducción de señales por unión a proteínas que contengan residuos de fosfoserina. Esta familia de proteínas se encuentra altamente conservada y es encontrada tanto en plantas como en mamíferos. La proteína YWHAB interacciona con las fosfatasas RAF1 y CDC25, lo que sugiere que podría desempeñar un papel en señalización de mitosis y en la maquinaria del ciclo celular. Se han descrito dos variantes transcripcionales que codifican la misma proteína.^[2]

Interacciones

La proteína YWHAB ha demostrado ser capaz de interaccionar con:

CDC25A^[3]
CDC25B^[4]^[3]
BRAF^[5]^[6]
c-Raf^[7]^[8]^[9]^[10]^[11]^[3]
RPS6KA1^[12]
EPB41L3^[5]^[13]
CD29^[14]
Proteína quinasa Wee1-like^[15]
PTPN3^[16]
Proteína quinasa Mζ^[9]
MAPK7^[17]
TESK1^[18]
TNFAIP3^[11]
Cbl^[19]
HDAC4^[20]
KCNK3^[21]

Véase también

Proteínas 14-3-3

Referencias

[1]
Tommerup N, Leffers H (Jun de 1996). «Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization». Genomics 33 (1): 149-50. PMID 8617504. doi:10.1006/geno.1996.0176.
[2]
«Entrez Gene: YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide».
[3]
Conklin, D S; Galaktionov K; Beach D (Aug. de 1995). «14-3-3 proteins associate with cdc25 phosphatases». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (17): 7892-6. ISSN 0027-8424. PMID 7644510.
[4]
Mils, V; Baldin V; Goubin F; Pinta I; Papin C; Waye M; Eychene A; Ducommun B (Mar. de 2000). «Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase». Oncogene (ENGLAND) 19 (10): 1257-65. ISSN 0950-9232. PMID 10713667. doi:10.1038/sj.onc.1203419.
[5]
Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.
[6]
Qiu, W; Zhuang S, von Lintig F C, Boss G R, Pilz R B (Oct. de 2000). «Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins». J. Biol. Chem. (UNITED STATES) 275 (41): 31921-9. ISSN 0021-9258. PMID 10931830. doi:10.1074/jbc.M003327200.
[7]
Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543. PMID 12620389.
[8]
Truong, Amy B; Masters Shane C, Yang Hongzhu, Fu Haian (Nov. de 2002). «Role of the 14-3-3 C-terminal loop in ligand interaction». Proteins (United States) 49 (3): 321-5. PMID 12360521. doi:10.1002/prot.10210.
[9]
Van Der Hoeven, P C; Van Der Wal J C, Ruurs P, Van Dijk M C, Van Blitterswijk J (Jan. de 2000). «14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation». Biochem. J. (ENGLAND). 345 Pt 2: 297-306. ISSN 0264-6021. PMID 10620507.
[10]
Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (Jul. de 2000). «Isoform-specific localization of A-RAF in mitochondria». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870-8. ISSN 0270-7306. PMID 10848612.
[11]
Vincenz, C; Dixit V M (Aug. de 1996). «14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules». J. Biol. Chem. (UNITED STATES) 271 (33): 20029-34. ISSN 0021-9258. PMID 8702721.
[12]
Cavet, Megan E; Lehoux Stephanie, Berk Bradford C (mayo. de 2003). «14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity». J. Biol. Chem. (United States) 278 (20): 18376-83. ISSN 0021-9258. PMID 12618428. doi:10.1074/jbc.M208475200.
[13]
Yu, Tingxi; Robb Victoria A, Singh Vinita, Gutmann David H, Newsham Irene F (Aug. de 2002). «The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins». Biochem. J. (England) 365 (Pt 3): 783-9. ISSN 0264-6021. PMID 11996670. doi:10.1042/BJ20020060.
[14]
Han, D C; Rodriguez L G, Guan J L (Jan. de 2001). «Identification of a novel interaction between integrin beta1 and 14-3-3beta». Oncogene (England) 20 (3): 346-57. ISSN 0950-9232. PMID 11313964. doi:10.1038/sj.onc.1204068.
[15]
Wang, Y; Jacobs C, Hook K E, Duan H, Booher R N, Sun Y (Apr. de 2000). «Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population». Cell Growth Differ. (UNITED STATES) 11 (4): 211-9. ISSN 1044-9523. PMID 10775038.
[16]
Zhang, S H; Kobayashi R, Graves P R, Piwnica-Worms H, Tonks N K (Oct. de 1997). «Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein». J. Biol. Chem. (UNITED STATES) 272 (43): 27281-7. ISSN 0021-9258. PMID 9341175.
[17]
Zheng, Qinlei; Yin Guoyong, Yan Chen, Cavet Megan, Berk Bradford C (Mar. de 2004). «14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function». J. Biol. Chem. (United States) 279 (10): 8787-91. ISSN 0021-9258. PMID 14679215. doi:10.1074/jbc.M310212200.
[18]
Toshima, J Y; Toshima J; Watanabe T; Mizuno K (Nov. de 2001). «Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1». J. Biol. Chem. (United States) 276 (46): 43471-81. ISSN 0021-9258. PMID 11555644. doi:10.1074/jbc.M104620200.
[19]
Robertson, H; Langdon W Y, Thien C B, Bowtell D D (Nov. de 1997). «A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components». Biochem. Biophys. Res. Commun. (UNITED STATES) 240 (1): 46-50. ISSN 0006-291X. PMID 9367879. doi:10.1006/bbrc.1997.7608.
[20]
Grozinger, C M; Schreiber S L (Jul. de 2000). «Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7835-40. ISSN 0027-8424. PMID 10869435. doi:10.1073/pnas.140199597.
[21]
O'Kelly, Ita; Butler Margaret H, Zilberberg Noam, Goldstein Steve A N (Nov. de 2002). «Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals». Cell (United States) 111 (4): 577-88. ISSN 0092-8674. PMID 12437930.

Interacciones

Véase también

Referencias

Enlaces externos

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