HAP1

APEX1
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1BIX, 1CQH, 4LND, 4QH9, 5DFF, 4QHD, 1E9N, 3U8U, 5DFI, 1HD7, 5DG0, 5DFJ, 4QHE, 5DFH, 1DE9, 4IEM, 2ISI, 1DE8, 2O3H, 1CQG, 1DEW, 5CFG
Identifiants
Alias	APEX1
IDs externes	OMIM: 107748 MGI: 88042 HomoloGene: 1241 GeneCards: APEX1
Position du gène (humain)
Chr.	Chromosome 14 humain
Fin	20,457,772 bp
Position du gène (souris)
Chr.	Chromosome 14 (souris)
Fin	51,164,596 bp
Expression génique
	Fortement exprimé dans
	éminence ganglionnaire; ; ventricular zone; ; îlot de Langerhans; ; right adrenal gland; ; right adrenal cortex; ; left ovary; ; right ovary; ; left adrenal cortex; ; vésicule biliaire; ; rectum;
	Fortement exprimé dans
	ligne primitive; ; artère carotide interne; ; artère carotide externe; ; paroi abdominale; ; épiblaste; ; condyle; ; maxillary prominence; ; mandibular prominence; ; medial ganglionic eminence; ; embryon;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison ADN; activité nucléase; endonuclease activity; activité hydrolase; liaison ion métal; activité lyase; class I DNA-(apurinic or apyrimidinic site) endonuclease activity; liaison de complexe macromoléculaire; liaison protéique; exonuclease activity; phosphodiesterase I activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; endodeoxyribonuclease activity; chromatin DNA binding; endoribonuclease activity; uracil DNA N-glycosylase activity; phosphoric diester hydrolase activity; site-specific endodeoxyribonuclease activity, specific for altered base; double-stranded telomeric DNA binding; activité d'oxydoréductase; double-stranded DNA exodeoxyribonuclease activity; transcription coactivator activity; NF-kappaB binding; RNA-DNA hybrid ribonuclease activity; damaged DNA binding; transcription corepressor activity; 3'-5' exonuclease activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; liaison ARN; class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity;
Composant cellulaire	cytoplasme; centrosome; intracellulaire; mitochondrie; noyau; perinuclear region of cytoplasm; ribosome; transcription regulator complex; nuclear speck; nucléoplasme; nucléole; réticulum endoplasmique;
Processus biologique	réparation de l'ADN; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; DNA recombination; positive regulation of G1/S transition of mitotic cell cycle; negative regulation of smooth muscle cell migration; regulation of transcription, DNA-templated; DNA demethylation; cellular response to cAMP; RNA phosphodiester bond hydrolysis, endonucleolytic; transcription, DNA-templated; response to organonitrogen compound; cellular response to hydrogen peroxide; cellular response to peptide hormone stimulus; regulation of mRNA stability; cellular response to organonitrogen compound; cell redox homeostasis; vieillissement; base-excision repair; maintien des télomères; negative regulation of nucleic acid-templated transcription; telomere maintenance via base-excision repair; regulation of apoptotic process; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologues
	328
	11792
	ENSG00000100823
	ENSMUSG00000035960
	P27695
	P28352
	NM_001244249; NM_001641; NM_080648; NM_080649
	NM_009687
	NP_001231178; NP_001632; NP_542379; NP_542380
	NP_033817
	Wikidata
Voir/Editer Humain	Voir/Editer Souris