HDAC4

HDAC4
	Domaine catalytique Hdac4. PDB2vqj
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
Identifiants
Alias	HDAC4
IDs externes	OMIM: 605314 MGI: 3036234 HomoloGene: 55946 GeneCards: HDAC4
Position du gène (humain)
Chr.	Chromosome 2 humain
Fin	239,401,654 bp
Position du gène (souris)
Chr.	Chromosome 1 (souris)
Fin	92,123,421 bp
Expression génique
	Fortement exprimé dans
	nerf sural; ; muscle glutéal; ; muscle gastrocnémien; ; muscle tibial antérieur; ; muscle de la cuisse; ; muscle layer of sigmoid colon; ; cellule endothéliale; ; muscle deltoïde; ; Skeletal muscle tissue of biceps brachii; ; sang;
	Fortement exprimé dans
	Vesicula otica; ; granulocyte; ; gastrula; ; Rostral migratory stream; ; dentate gyrus of hippocampal formation granule cell; ; muscle de la cuisse; ; lèvre; ; septum interventriculaire; ; tissu musculaire; ; skeletal muscle tissue;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; liaison ADN; transcription corepressor activity; histone deacetylase activity; zinc ion binding; transcription factor binding; liaison d'histone déacétylase; potassium ion binding; liaison de chromatine; liaison ion métal; liaison protéique; protein kinase binding; activité hydrolase; protein deacetylase activity; identical protein binding; promoter-specific chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; SUMO transferase activity;
Composant cellulaire	cytoplasme; histone deacetylase complex; plaque motrice; transcription repressor complex; sarcomère; Z discdkac; A band; actomyosin; noyau; cytosol; nucléoplasme; complexe macromoléculaire;
Processus biologique	positive regulation of reactive oxygen species biosynthetic process; histone H3 deacetylation; skeletal system development; Remodelage de la chromatine; peptidyl-lysine deacetylation; regulation of cardiac muscle contraction by calcium ion signaling; negative regulation of glycolytic process; response to interleukin-1; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; cellular response to tumor necrosis factor; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; positive regulation of protein sumoylation; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; transcription, DNA-templated; neurodéveloppement; regulation of striated muscle cell differentiation; régulation positive de la transcription dépendante de l'ADN; positive regulation of smooth muscle cell migration; B cell activation; histone H4 deacetylation; cellular response to mechanical stimulus; positive regulation of neuron apoptotic process; cardiac muscle hypertrophy in response to stress; positive regulation of cell population proliferation; negative regulation of myotube differentiation; response to denervation involved in regulation of muscle adaptation; regulation of skeletal muscle fiber development; osteoblast development; B cell differentiation; cellular response to parathyroid hormone stimulus; réponse inflammatoire; positive regulation of lamellipodium assembly; regulation of protein binding; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; positive regulation of smooth muscle cell proliferation; organisation de la chromatine; negative regulation of pri-miRNA transcription by RNA polymerase II; protein deacetylation; Sumoylation; positive regulation of male mating behavior;
	Sources:Amigo / QuickGO
Orthologues
	9759
	208727
	ENSG00000068024
	ENSMUSG00000026313
	P56524
	Q6NZM9
	NM_006037; NM_001378414; NM_001378415; NM_001378416; NM_001378417
	NM_207225
	NP_006028; NP_001365343; NP_001365344; NP_001365345; NP_001365346
	NP_997108
	Wikidata
Voir/Editer Humain	Voir/Editer Souris