PIK3CA

PIK3CA
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP
Identifiants
Alias	PIK3CA
IDs externes	OMIM: 171834 MGI: 1206581 HomoloGene: 21249 GeneCards: PIK3CA
Nomenclature EC	2.7.11.1
Position du gène (humain)
Chr.	Chromosome 3 humain
Fin	179,240,093 bp
Position du gène (souris)
Chr.	Chromosome 3 (souris)
Fin	32,522,635 bp
Expression génique
	Fortement exprimé dans
	tendon calcanéen; ; gonade; ; testicule; ; tendon of biceps brachii; ; ventricular zone; ; secondary oocyte; ; éminence ganglionnaire; ; cartilage tissue; ; ventricule droit; ; skin of hip;
	Fortement exprimé dans
	Rostral migratory stream; ; glande lacrymale; ; iris; ; corps mamillaires; ; lobe of cerebellum; ; corps géniculé latéral; ; aorte ascendante; ; Vermis du cervelet; ; tubercule génital; ; corps ciliaire;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	activité de transférase; liaison nucléotide; protein kinase activator activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; protein serine/threonine kinase activity; liaison protéique; insulin receptor substrate binding; liaison ATP; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; activité kinase; phosphatidylinositol 3-kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity;
Composant cellulaire	phosphatidylinositol 3-kinase complex; cytosol; phosphatidylinositol 3-kinase complex, class IA; membrane plasmique; lamellipode; cytoplasme; membrane;
Processus biologique	negative regulation of neuron apoptotic process; cardiac muscle contraction; epidermal growth factor receptor signaling pathway; protein kinase B signaling; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of multicellular organism growth; T cell costimulation; hypomethylation of CpG island; positive regulation of peptidyl-serine phosphorylation; platelet activation; Fc-epsilon receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; vascular endothelial growth factor receptor signaling pathway; vasculature development; angiogenèse; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; glucose metabolic process; phagocytose; energy homeostasis; negative regulation of fibroblast apoptotic process; régulation de l'expression des gènes; liver development; adipose tissue development; regulation of cellular respiration; T cell receptor signaling pathway; activation of protein kinase activity; regulation of genetic imprinting; negative regulation of anoikis; cellular response to glucose stimulus; endothelial cell migration; phosphatidylinositol-mediated signaling; leukocyte migration; ERBB2 signaling pathway; phosphatidylinositol-3-phosphate biosynthetic process; Guidage axonal; negative regulation of macroautophagy; phosphorylation; positive regulation of TOR signaling; Anoïkose; adaptive immune response; phosphorylation des protéines; réponse inflammatoire; système immunitaire inné; cell chemotaxis; G protein-coupled receptor signaling pathway; positive regulation of protein kinase B signaling; phosphatidylinositol 3-kinase signaling; cytokine-mediated signaling pathway; migration cellulaire; positive regulation of phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; regulation of protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologues
	5290
	18706
	ENSG00000121879
	ENSMUSG00000027665
	P42336
	P42337
	NM_006218
	NM_008839
	NP_006209
	NP_032865
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasPIK3CA

IDs externesOMIM: 171834 MGI: 1206581 HomoloGene: 21249 GeneCards: PIK3CA

Nomenclature EC2.7.11.1

Le PIK3CA est une protéine constituant la sous unité alpha de la phosphatidylinositol-3,4-bisphosphate kinase. Son gène est le PIK3CA situé sur le chromosome 3 humain.

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PIK3CA

Cible thérapeutique

Notes et références

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