TREM2

TREM2
Identifiants
Alias	TREM2
IDs externes	OMIM: 605086 MGI: 1913150 HomoloGene: 10352 GeneCards: TREM2
Position du gène (humain)
Chr.	Chromosome 6 humain
Fin	41,163,186 bp
Position du gène (souris)
Chr.	Chromosome 17 (souris)
Fin	48,661,175 bp
Expression génique
	Fortement exprimé dans
	C1 segment; ; liquide amniotique; ; ganglion inférieur du nerf vague; ; substantia nigra; ; nerf optique; ; artère coronaire droite; ; vésicule biliaire; ; left adrenal gland; ; noyau sous-thalamique; ; upper lobe of left lung;
	Fortement exprimé dans
	tissu adipeux blanc; ; striatum of neuraxis; ; hippocampus proper; ; vessie; ; dentate gyrus of hippocampal formation granule cell; ; corps calleux; ; gyrus frontal supérieur; ; mésenchyme; ; ovaire; ; bulbe olfactif;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	scaffold protein binding; lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan binding; phospholipid binding; signaling receptor activity; amyloid-beta binding; high-density lipoprotein particle binding; liaison lipidique; low-density lipoprotein particle binding; apolipoprotein binding; apolipoprotein A-I binding; very-low-density lipoprotein particle binding; liaison de complexe macromoléculaire; lipoprotein particle binding; protein tyrosine kinase binding; liaison protéique;
Composant cellulaire	integral component of membrane; membrane; région extracellulaire; membrane plasmique; integral component of plasma membrane; intrinsic component of plasma membrane;
Processus biologique	dendritic cell differentiation; positive regulation of CD40 signaling pathway; positive regulation of calcium-mediated signaling; positive regulation of C-C chemokine receptor CCR7 signaling pathway; phagocytosis, engulfment; detection of peptidoglycan; humoral immune response; cellular response to lipoteichoic acid; positive regulation of protein localization to plasma membrane; regulation of immune response; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipoteichoic acid; système immunitaire inné; detection of lipopolysaccharide; cellular response to peptidoglycan; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of ERK1 and ERK2 cascade; transduction de signal; osteoclast differentiation; positive regulation of macrophage fusion; positive regulation of amyloid-beta clearance; positive regulation of protein phosphorylation; régulation de l'expression des gènes; negative regulation of autophagy; positive regulation of gene expression; positive regulation of mitochondrion organization; regulation of TOR signaling; positive regulation of TOR signaling; regulation of interleukin-6 production; regulation of peptidyl-tyrosine phosphorylation; positive regulation of chemotaxis; regulation of resting membrane potential; positive regulation of astrocyte activation; regulation of macrophage inflammatory protein 1 alpha production; import into cell; regulation of plasma membrane bounded cell projection organization; positive regulation of proteasomal protein catabolic process; positive regulation of inward rectifier potassium channel activity; regulation of intracellular signal transduction; positive regulation of microglial cell activation; negative regulation of autophagic cell death; positive regulation of microglial cell migration; cellular response to amyloid-beta; positive regulation of CAMKK-AMPK signaling cascade; positive regulation of ATP biosynthetic process; apoptotic cell clearance; positive regulation of protein secretion; microglial cell activation; response to ischemia; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; positive regulation of interleukin-10 production; negative regulation of apoptotic process; positive regulation of osteoclast differentiation; positive regulation of NIK/NF-kappaB signaling; microglial cell activation involved in immune response; defense response to bacterium; regulation of innate immune response; positive regulation of phagocytosis, engulfment; microglial cell proliferation; amyloid-beta clearance; complement-mediated synapse pruning; neuroinflammatory response; positive regulation of neuroinflammatory response; positive regulation of engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologues
	54209
	83433
	ENSG00000095970
	ENSMUSG00000023992
	Q9NZC2
	Q99NH8
	NM_001271821; NM_018965
	NM_001272078; NM_031254
	NP_001258750; NP_061838
	NP_001259007; NP_112544
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

AliasTREM2

IDs externesOMIM: 605086 MGI: 1913150 HomoloGene: 10352 GeneCards: TREM2

Chr.Chromosome 6 humain^[1]

Fin41,163,186 bp^[1]

La TREM2 (« triggering receptor expressed on myeloid cells 2 ») est une protéine membranaire codée par le gène TREM2 situé sur le chromosome 6 humain.

[1]

[2]

[3]

[4]

TREM2

Maladies liées à une dysfonction ou à l'absence de la protéine TREM2

Voir aussi

Notes et références

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