Mre11

MRE11
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	3T1I
識別子
記号	MRE11, ATLD, HNGS1, MRE11B, MRE11A, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease
外部ID	OMIM: 600814 MGI: 1100512 HomoloGene: 4083 GeneCards: MRE11
遺伝子の位置 (ヒト)
染色体	11番染色体 (ヒト)
終点	94,493,885 bp
遺伝子の位置 (マウス)
染色体	9番染色体 (マウス)
終点	14,748,419 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • manganese ion binding; • DNA helicase activity; • single-stranded DNA endodeoxyribonuclease activity; • protein C-terminus binding; • 血漿タンパク結合; • 3'-5' exonuclease activity; • ヌクレアーゼ活性; • エンドヌクレアーゼ活性; • 二本鎖DNA結合; • endodeoxyribonuclease activity; • エキソヌクレアーゼ活性; • 加水分解酵素活性; • cadherin binding; • identical protein binding; • 3'-5'-exodeoxyribonuclease activity; • 5'-3' exonuclease activity;
細胞の構成要素	• site of double-strand break; • 細胞質基質; • PML body; • 細胞核; • 細胞質; • 核質; • テロメア; • 染色体; • MRX複合体; • replication fork;
生物学的プロセス	• reciprocal meiotic recombination; • DNA recombination; • telomere maintenance via telomerase; • positive regulation of kinase activity; • mitotic intra-S DNA damage checkpoint signaling; • telomeric 3' overhang formation; • negative regulation of apoptotic process; • 染色体構成; • sister chromatid cohesion; • DNA損傷刺激に対する細胞応答; • positive regulation of telomere maintenance; • DNA duplex unwinding; • homologous chromosome pairing at meiosis; • negative regulation of DNA endoreduplication; • double-strand break repair; • 減数分裂; • double-strand break repair via homologous recombination; • positive regulation of protein autophosphorylation; • 細胞増殖; • mitotic G2 DNA damage checkpoint signaling; • viral process; • double-strand break repair via nonhomologous end joining; • positive regulation of type I interferon production; • regulation of mitotic recombination; • DNA修復; • 核酸ホスホジエステル結合の加水分解; • DNA double-strand break processing; • strand displacement; • DNA複製; • DNA synthesis involved in DNA repair; • regulation of signal transduction by p53 class mediator; • telomere maintenance; • meiotic DNA double-strand break formation; • mitochondrial double-strand break repair via homologous recombination; • DNA strand resection involved in replication fork processing;
	出典:Amigo / QuickGO
オルソログ
	4361
	17535
	ENSG00000020922
	ENSMUSG00000031928
	P49959
	Q61216
	NM_005590; NM_005591; NM_001330347
	NM_018736; NM_001310728
	NP_001317276; NP_005581; NP_005582
	NP_001297657; NP_061206
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス