1-Methyl-DMT
Pharmaceutical compound
From Wikipedia, the free encyclopedia
1-Methyl-DMT, or 1-Me-DMT, also known as 1-methyl-N,N-dimethyltryptamine or as 1,N,N-trimethyltryptamine (1,N,N-TMT or 1-TMT), is a serotonin receptor modulator of the tryptamine family related to dimethyltryptamine (DMT) and lespedamine (1-methoxy-DMT).[1]
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| Other names | 1-Me-DMT; 1-Methyl-N,N-dimethyltryptamine; 1,N,N-Timethyltryptamine; 1,N,N-TMT; 1-TMT; N,N,1-Trimethyltryptamine |
| Drug class | Serotonin receptor modulator; Psychoplastogen |
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| Formula | C13H18N2 |
| Molar mass | 202.301 g·molâ1 |
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Pharmacology
Pharmacodynamics
1-Methyl-DMT appears to have similar affinity for serotonin receptors as DMT, but is more toxic than DMT in rodents.[1][2][3] In another study, it showed 3-fold higher affinity for the serotonin 5-HT2A receptor than DMT.[4][5] In a further study, it showed abolished affinity for the 5-HT1E receptor and 30-fold lower affinity for the serotonin 5-HT1F receptor than DMT.[6] 1-Methyl-DMT shows comparable psychoplastogenic effects in preclinical research to DMT.[7][8]
Chemistry
Synthesis
The chemical synthesis of 1-methyl-DMT has been described.[7]
Analogues
Analogues of 1-methyl-DMT include dimethyltryptamine (DMT), 1-methyltryptamine, lespedamine (1-MeO-DMT), 1-methylpsilocin (1-Me-4-HO-DMT; CMY-16), 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, 6-methyl-DMT, and 7-methyl-DMT, among others.[1]
History
The drug was briefly mentioned by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).[1] 1-Methyl-DMT was first described in the scientific literature by Richard Glennon and colleagues in 1979.[2][3]