CORT-108297

CORT-108297, also known as ADS-108297, is a nonsteroidal selective glucocorticoid receptor modulator (SEGRM) with mixed glucocorticoid and antiglucocorticoid actions which is under development for the treatment of Alzheimer's disease, cognition disorders, memory disorders, and post-traumatic stress disorder (PTSD).^[1][2][3][4] It was also being developed for treatment of other psychiatric disorders and weight gain, but development for these indications was discontinued.^[1] The drug is taken by mouth.^[1] As of November 2022, CORT-108297 is in phase 2 clinical trials for the aforementioned active indications.^[1][2]

Other namesCORT108297; ADS-108297; ADS108297

Routes of
administrationOral^[1]

Drug classAntiglucocorticoid; Selective glucocorticoid receptor modulator

ATC code

• None

Quick facts Clinical data, Other names ...

CORT-108297

Clinical data
Other names	CORT108297; ADS-108297; ADS108297
Routes of administration	Oral[1]
Drug class	Antiglucocorticoid; Selective glucocorticoid receptor modulator
ATC code	None
Identifiers
IUPAC name (4aR)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinoline
CAS Number	1018679-79-2
PubChem CID	44454750
ChemSpider	23322313
UNII	A17W0640NB
ChEMBL	ChEMBL271220
CompTox Dashboard (EPA)	DTXSID70144304
Chemical and physical data
Formula	C26H25F4N3O3S
Molar mass	535.56 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC[C@]12CC3=C(C=C1CCN(C2)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F)N(N=C3)C5=CC=C(C=C5)F
InChI InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1 Key:SLKURXRZHJOZOD-RUZDIDTESA-N

Close