Dazucorilant

Dazucorilant
Clinical data
Other names	CORT-113176
Identifiers
	IUPAC name [(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone;
CAS Number	1496508-34-9;
PubChem CID	72192163;
DrugBank	DB18025;
ChemSpider	58919795;
UNII	HR4RD5RBJ6;
KEGG	D12638;
ChEMBL	ChEMBL3734774;
Chemical and physical data
Formula	C29H22F4N4O3S
Molar mass	582.57 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(C[C@@]2(C1=CC3=C(C2)C=NN3C4=CC=C(C=C4)F)C(=O)C5=CC=CC=N5)S(=O)(=O)C6=CC=C(C=C6)C(F)(F)F;
	InChI InChI=1S/C29H22F4N4O3S/c30-22-6-8-23(9-7-22)37-26-15-21-12-14-36(41(39,40)24-10-4-20(5-11-24)29(31,32)33)18-28(21,16-19(26)17-35-37)27(38)25-3-1-2-13-34-25/h1-11,13,15,17H,12,14,16,18H2/t28-/m0/s1; Key:VXOBXKQLNWYQPQ-NDEPHWFRSA-N;

Dazucorilant (CORT-113176) is an example of a selective glucocorticoid receptor modulator that is in clinical development.^[1] It is expected to have uses in the treatment of neurodegenerative diseases, Alzheimer's disease and Huntington's chorea, for example.^[2]^[3]^[4]

Other namesCORT-113176

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