Eukaryotic translation initiation factor 4 gamma 1

The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.^[7] eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3.

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,^[8] EIF4A1,^[9][10][11] EIF4E,^{[10][11][12][13][14]} MKNK2^[15] and PABPC1.^[16]

• Eukaryotic initiation factor