Eukaryotic translation initiation factor 4 gamma 1

The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure (carried out by the eIF4A subunit), and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.^[7] eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3. It also facilitates the loading of the small ribosomal subunit onto the mRNA.^[8]

eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory through promoting translation of select mRNAs, although it has a general role in canonical eukaryotic translation initiation ^[9]

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,^[10] EIF4A1,^[11][12][13] EIF4E,^{[12][13][14][15][16]} MKNK2^[17] and PABPC1.^[18]

• Eukaryotic initiation factor