GNAI2

GNAI2
Identifiers
Aliases	GNAI2, GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1, G protein subunit alpha i2, HG1C
External IDs	OMIM: 139360; MGI: 95772; GeneCards: GNAI2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,259,362 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,512,566 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right lung; ; stromal cell of endometrium; ; C1 segment; ; right coronary artery; ; upper lobe of left lung; ; thoracic aorta; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	Ileal epithelium; ; granulocyte; ; external carotid artery; ; lactiferous gland; ; internal carotid artery; ; median eminence; ; entorhinal cortex; ; perirhinal cortex; ; choroid plexus of fourth ventricle; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; G-protein beta/gamma-subunit complex binding; signal transducer activity; metal ion binding; protein binding; guanyl nucleotide binding; G protein-coupled receptor binding; GTP binding; GTPase activity;
Cellular component	cytoplasm; cell body; extracellular vesicle; centrosome; membrane; plasma membrane; nucleoplasm; microtubule organizing center; dendrite; midbody; heterotrimeric G-protein complex; membrane raft; extracellular exosome; cytoskeleton; nucleus; cytosol;
Biological process	gamma-aminobutyric acid signaling pathway; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled adenosine receptor signaling pathway; negative regulation of adenylate cyclase activity; intracellular signal transduction; regulation of calcium ion transport; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; response to nutrient; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of synaptic transmission; cell division; positive regulation of cell population proliferation; cell cycle; cell population proliferation; signal transduction; protein folding; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cell migration; positive regulation of superoxide anion generation; positive regulation of NAD(P)H oxidase activity; positive regulation of urine volume; positive regulation of renal sodium excretion; negative regulation of calcium ion-dependent exocytosis; positive regulation of insulin receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of protein tyrosine phosphatase activity; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of neural precursor cell proliferation; negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2771
	14678
	ENSG00000114353
	ENSMUSG00000032562
	P04899
	P08752
NM_002070; NM_001166425; NM_001282617; NM_001282618; NM_001282619;
	NM_001282620
	NM_008138
NP_001159897; NP_001269546; NP_001269547; NP_001269548; NP_001269549;
	NP_002061
	NP_032164
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.^[5]^[6]^[7] This protein is one of the 4 subunits in the G_i/o family of G-proteins, which together play an important role in inhibitory signaling. Some preliminary evidence suggests that the alpha-2 subunit in particular may be important for adenosine A1 receptor signaling. The A1 receptor is a target of certain drugs that treat tachycardia,^[8] and also part of the mechanism of certain stimulants like caffeine (via receptor antagonism). Somatic mutations in the gene have been associated with certain diseases like ventricular tachycardia.