Glycoside hydrolase family 13
From Wikipedia, the free encyclopedia
| Alpha amylase, N-terminal ig-like domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of thermoactinomyces vulgaris r-47 alpha-amylase 1 (tvai) mutant d356n/e396q complexed with p2, a pullulan model oligosaccharide | |||||||||
| Identifiers | |||||||||
| Symbol | Alpha-amylase_N | ||||||||
| Pfam | PF02903 | ||||||||
| InterPro | IPR004185 | ||||||||
| SCOP2 | 1sma / SCOPe / SUPFAM | ||||||||
| |||||||||
| Alpha-amylase catalytic domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 cyclodextrin glucanotransferase (e.c.2.4.1.19) (cgtase) | |||||||||
| Identifiers | |||||||||
| Symbol | Alpha-amylase | ||||||||
| Pfam | PF00128 | ||||||||
| Pfam clan | CL0058 | ||||||||
| InterPro | IPR006047 | ||||||||
| SCOP2 | 1ppi / SCOPe / SUPFAM | ||||||||
| CAZy | GH13 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 13 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Enzymes containing this domain belong to family 13 (CAZY GH_13) of the glycosyl hydrolases. The maltogenic alpha-amylase is an enzyme which catalyses hydrolysis of (1-4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains in the conversion of starch to maltose. Other enzymes in this family include neopullulanase, which hydrolyses pullulan to panose, and cyclomaltodextrinase, which hydrolyses cyclodextrins.
