From 1996 to 2007, she worked on the continuous news channel LCI as a reporter and then as a news presenter. In June 2007, she joined BFM TV for the third version of the continuous news channel and presents of the morning news Première édition with Christophe Delay.[1] Télé 7 Jours estimated in June 2008 that she brought "professionalism and mischief" at that news session.
In August 2009, Karine de Ménonville started co-hosting Info 360 with Ronald Guintrange.[2][3] Going to maternity leave from February to May 2010, she is replaced by Stéphanie de Muru[4] and at her return in June, Thomas Misrachi began co-hosting the program.[5] In August 2010, Karine de Ménonville started again co-hosting the midday part with Stéphanie de Muru and Gilane Barret,[6][7] and only with Gilane Barret after the departure for maternity leave of Stéphanie de Muru. In September 2012, she presents again with Ronald Guintrange on the Midi|15H, after the departure of Gilane Barret for the weekday afternoon edition of Non-Stop.