LU domain
From Wikipedia, the free encyclopedia
| u-PAR/Ly-6 domain | |||||||||||
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| Identifiers | |||||||||||
| Symbol | UPAR_LY6 | ||||||||||
| Pfam | PF00021 | ||||||||||
| InterPro | IPR001526 | ||||||||||
| PROSITE | PDOC00756 | ||||||||||
| CATH | 1erg | ||||||||||
| SCOP2 | 1erg / SCOPe / SUPFAM | ||||||||||
| CDD | cd00117 | ||||||||||
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The LU domain (Ly-6 antigen/uPAR) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.[2][3]
A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved LU domain of about 100 amino-acid residues.[4][5] Among these proteins, most contain only a single LU domain, though small numbers of exceptions are known; well-studied family member uPAR has three tandem LU domains.[3]
This domain folds into five antiparallel beta sheets, a structure common to the three-finger protein family. The domain typically contains ten well-conserved cysteine residues involved in five disulfide bonds, though some examples such as two of the three uPAR domains have fewer.[3]