Moguisteine

CAS Number

• 119637-67-1 ^Y

PubChem CID

• 65935

ChemSpider

• 59340

UNII

• 6Y556547YY

Moguisteine

Identifiers
IUPAC name Ethyl 3-{2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl}-3-oxopropanoate
CAS Number	119637-67-1 Y
PubChem CID	65935
ChemSpider	59340
UNII	6Y556547YY
ChEMBL	ChEMBL146980
CompTox Dashboard (EPA)	DTXSID00869634
Chemical and physical data
Formula	C16H21NO5S
Molar mass	339.41 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(=O)CC(=O)N1CCSC1COC2=CC=CC=C2OC
InChI InChI=1S/C16H21NO5S/c1-3-21-16(19)10-14(18)17-8-9-23-15(17)11-22-13-7-5-4-6-12(13)20-2/h4-7,15H,3,8-11H2,1-2H3 Key:WSYVIAQNTFPTBI-UHFFFAOYSA-N

Moguisteine is a non-narcotic, peripherally acting antitussive.^[1] In a small double-blind, randomized controlled trial, 200 mg of moguisteine suspension taken 3 times daily significantly reduced the frequency of coughing in patients with COPD, compared to placebo.^[2] It has also been studied in small trials in comparison to codeine^[3] and dextromethorphan,^[4] and has similar efficacy to both. It has not been approved for use in the United States.^[5]

It was discovered by searching for expectorants of the thiazolidine class, when compounds with a cough suppressant effect were accidentally found and moguisteine was selected as the most effective and safest representative of the class.^[6] Its mechanism of action may be the activation of ATP-sensitive potassium channels.^[7]