NAS-181

Serotonin 5-HT1B receptor antagonist From Wikipedia, the free encyclopedia

NAS-181, also known as MCOMM, is a selective rodent serotonin 5-HT1B receptor antagonist which is used in scientific research.[1][2]

Other namesNAS181; MCOMM
Drug classSerotonin 5-HT1B receptor antagonist
CAS Number
PubChem CID
Quick facts Clinical data, Other names ...
NAS-181
Clinical data
Other namesNAS181; MCOMM
Drug classSerotonin 5-HT1B receptor antagonist
Identifiers
  • (2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine
CAS Number
PubChem CID
UNII
ChEMBL
Chemical and physical data
FormulaC19H26N2O4
Molar mass346.427 g·mol−1
3D model (JSmol)
  • C1CO[C@H](CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4
  • InChI=1S/C19H26N2O4/c1-2-16-10-15(12-21-5-8-22-9-6-21)13-25-19(16)18(3-1)24-14-17-11-20-4-7-23-17/h1-3,10,17,20H,4-9,11-14H2/t17-/m1/s1
  • Key:RTKDBEOSPDFLGD-QGZVFWFLSA-N
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In animals, NAS-181 has been found to strongly increase acetylcholine levels in the frontal cortex and hippocampus.[3][4] It has been found to block memory impairment induced by the antimuscarinic agent scopolamine and by the NMDA receptor antagonist dizocilpine (MK-801).[5][6] Injection of NAS-181 directly into the nucleus accumbens has also been found to reverse the prosocial behavior induced by the serotonin releasing agent MDMA in animals.[7]

NAS-181 was first described in the scientific literature by 1998.[8] The drug was discovered by researchers at Astra Arcus.[2]

See also

References

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