Obocell
From Wikipedia, the free encyclopedia
Obocell is the brand name of a CNS stimulant and appetite suppressant (d-amphetamine phosphate) combined into one pill with a CNS depressant and first generation antihistamine (25mg methapyrilene). This combination formula was developed by Neisler Laboratories in 1951, approved for medical use in the United States by the U.S. Food and Drug Administration in 1953 to treat obesity.[1] According to the National Institutes of Health, production or availability of Obocell was discontinued around 1967.[2] It was approved for medical use in the U.S. in 1953, and available for over the counter sales between 1953 and 1967, in the dosage form of a tablet, and indicated for treating obesity in patients by functioning as an appetite suppressant.[3]
Obocell's formulation of active ingredients included a substituted amphetamine (5mg dextroamphetamine phosphate (a central nervous system/CNS stimulant and 25mg methapyrilene (a first generation H1-antihistamine) produced as a single tablet containing the 5mg:25mg dosage ratio, directed for oral consumption. A similar, yet distinct, product was marketed by Irwin, Neisler & Co. called Obocell-TF, which also included a ratio of 5mg dextroamphetamine phosphate and 25mg methapyrilene, with an additional component being Irwin, Neisler & Co.'s high-viscosity methylcellulose product (Nicel brand).[4][5]
