POLR2G

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesPOLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G

External IDsOMIM: 602013; MGI: 1914960; HomoloGene: 2019; GeneCards: POLR2G; OMA:POLR2G - orthologs

Chr.Chromosome 11 (human)^[1]

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POLR2G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C35, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G
External IDs	OMIM: 602013; MGI: 1914960; HomoloGene: 2019; GeneCards: POLR2G; OMA:POLR2G - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,761,565 bp[1] End 62,766,710 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,770,491 bp[2] End 8,775,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone granulocyte ganglionic eminence C1 segment right adrenal gland right adrenal cortex monocyte stromal cell of endometrium Descending thoracic aorta rectum Top expressed in medial ganglionic eminence endocardial cushion primary oocyte facial motor nucleus otic placode atrioventricular junction condyle primitive streak renal corpuscle mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity single-stranded DNA binding single-stranded RNA binding RNA binding nucleic acid binding translation initiation factor binding Cellular component P-body nucleoplasm RNA polymerase II, core complex nucleus Biological process mRNA splicing, via spliceosome positive regulation of nuclear-transcribed mRNA poly(A) tail shortening transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter positive regulation of translational initiation nuclear-transcribed mRNA catabolic process, exonucleolytic apoptotic process snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5436 67710 Ensembl ENSG00000168002 ENSMUSG00000071662 UniProt P62487 P62488 RefSeq (mRNA) NM_002696 NM_026329 RefSeq (protein) NP_002687 NP_080605 Location (UCSC) Chr 11: 62.76 – 62.77 Mb Chr 19: 8.77 – 8.78 Mb PubMed search [3] [4]
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This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.^[7]