Pleckstrin
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| Pleckstrin-1 | |||||||
|---|---|---|---|---|---|---|---|
 Ribbon diagram of the C-terminal pleckstrin homology domain of pleckstrin-1 bound to inositol 1,2,3,4,5-pentaphosphate (PDB ID 2I5C) | |||||||
| Identifiers | |||||||
| Symbol | PLEK | ||||||
| NCBI gene | 5341 | ||||||
| HGNC | 9070 | ||||||
| OMIM | 173570 | ||||||
| RefSeq | NM_002664 | ||||||
| UniProt | P08567 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p13.3 | ||||||
| |||||||
| Pleckstrin-2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PLEK2 | ||||||
| NCBI gene | 26499 | ||||||
| HGNC | 19238 | ||||||
| OMIM | 608007 | ||||||
| PDB | 1X1G | ||||||
| RefSeq | NM_016445 | ||||||
| UniProt | Q9NYT0 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q23.3q24.1 | ||||||
| Wikidata | Q18038260 | ||||||
| |||||||
Pleckstrins are a family of proteins found in platelets[1] and other cells. The name derives from platelet and leukocyte C kinase substrate and the KSTR string of amino acids. The prototype protein, now called pleckstrin-1, was first identified in 1979 as the major substrate of protein kinase C in platelets.[2] The homolog pleckstrin-2 is more widely expressed in tissues.[3]
The pleckstrin homology domain (PH domain) was named after pleckstrin-1.[2]
Both pleckstrin-1 and pleckstrin-2 contain two pleckstrin homology domains, separated by a central dishevelled-Egl10-pleckstrin (DEP) domain. Pleckstrin-1 is phosphorylated by protein kinase C on three serine and threonine residues located between the first pleckstrin homology domain and the DEP domain;[2] pleckstrin-2 is not a substrate for protein kinase C.[2][4] The two proteins share 65% sequence homology[2] and have a size of about 47 kilodaltons.[5]
As of 2024, no high-resolution three-dimensional structure has been solved for full-length pleckstrin, but the structures of the individual domains of both pleckstrin-1 and -2 have been published.[2]