Protein AATF
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.[5][6][7]
AliasesAATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor
External IDsOMIM: 608463; MGI: 1929608; HomoloGene: 40811; GeneCards: AATF; OMA:AATF - orthologs
Function
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[7]
Interactions
Protein AATF has been shown to interact with:
