SRI-42127

CAS Number

• 2727872-68-4

PubChem CID

• 163415849

ChemSpider

• 128921334

FormulaC₁₉H₂₀N₆O

SRI-42127

Identifiers
IUPAC name 3-(1H-indazol-6-yl)-N-methyl-N-(oxan-4-yl)imidazo[1,2-b]pyridazin-6-amine
CAS Number	2727872-68-4
PubChem CID	163415849
ChemSpider	128921334
Chemical and physical data
Formula	C19H20N6O
Molar mass	348.410 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C1CCOCC1)C2=NN3C(=NC=C3C4=CC5=C(C=C4)C=NN5)C=C2
InChI InChI=1S/C19H20N6O/c1-24(15-6-8-26-9-7-15)19-5-4-18-20-12-17(25(18)23-19)13-2-3-14-11-21-22-16(14)10-13/h2-5,10-12,15H,6-9H2,1H3,(H,21,22) Key:AEHZEVSNZUVPNR-UHFFFAOYSA-N

SRI-42127 is an experimental drug which acts to inhibit translocation of the RNA-binding HuR protein. HuR translocation promotes the production of inflammatory cytokines in glial cells, and inhibiting HuR has applications both in the treatment of some forms of cancer, and also neuropathic pain.^[1][2][3]