The High Fructose Adventures of Annoying Orange

Primary

• Orange (voiced by Dane Boedigheimer) is the main protagonist of the series. Much like his web counterpart, Orange is annoying, obnoxious, and partial to terrible puns, but deep down always means well, even though his quirks often drag his friends into ridiculous adventures. The series shows another side of Orange that differs from his YouTube persona and casts him as a wacky hero.
• Pear (voiced by Dane Boedigheimer) is Orange's best friend, often serving as the sole voice-of-reason in the fruit stand (though he usually goes ignored).
• Passion Fruit (voiced by Justine Ezarik) – Often referred to as "Passion", she is adorable, pragmatic, and smart. She has a crush on Orange, unlike the web series where the roles are reversed, to which Orange is completely oblivious, even though everyone else sees how obvious it is.
• Midget Apple/Little Apple (voiced by Dane Boedigheimer) is a grumpy small apple with a scrappy demeanor. He prefers to be called "Little Apple", and a running gag is that he will correct anyone who calls him "Midget Apple", which he hates being called.
• Marshmallow (voiced by Dane Boedigheimer) is a cute, eternally upbeat, and cheerful marshmallow.
• Grapefruit (voiced by Bob Jennings) is a hulking man-boy and prideful narcissist with an ego problem who thinks of himself as "large and in charge" and often brags about things he's yet to accomplish. He believes he is in a rivalry with Orange for Passion Fruit's affections, but she has no interest in him.
• Apple (voiced by Harland Williams) is an insecure and critical pessimist who rarely joins Orange's adventures for fear he will get bruised, though he usually ends up even worse off by staying behind. There is a running gag where Apple gets killed and/or maimed in every episode, similar to Kenny McCormick from South Park.
• Grandpa Lemon (voiced by Kevin Brueck) is the befuddled, elder statesman of the fruit stand. He thinks he is everybody's grandpa and has a habit of falling asleep mid-sentence.
• Nerville (played by Toby Turner) is an employee at Daneboe's Fruit Store, where he lives, and is the only human who can talk to the fruits (as other humans dismiss it as insanity). He is a close friend to the fruits.

Secondary

• Coconut (voiced by Tom Kenny) – Good-natured, but dim and hard-headed, Coconut is an occasional member of the gang, serving as the muscle when he does join.
• Peach (voiced by Felicia Day) is another member of the Fruit Gang, a peach who normally makes cameos.
• Broccoli Alien Overlord (voiced by Rob Paulsen) is an evil alien piece of broccoli, who speaks with an English accent, and serves as the main antagonist of the series. He is bent on enslaving Earth and becoming superior to fruit, though later his goals seem to be focused solely on destroying the Fruit Cart.
• Guava (voiced by Tom Kenny) is a member of the Fruit Gang who got women's legs after dreaming about them.
• Ginger (voiced by Felicia Day) is an organic ginger root who has a crush on Pear.
• Elderly Banana (voiced by Tom Sheppard) is an elderly, ripe banana with a passion for the macabre and scary when within the Fruit Gang.
• Big Rock Candy Monster (voiced by John DiMaggio) is a monster made entirely of rock candy and a native of the planet Marshmalia. Upset because marshmallows took their place in desserts, he swore revenge against them. After his initial appearance, he becomes a reoccurring character. He has also appeared in the Annoying Orange YouTube channel in a Gangnam Style parody video.

Special guest stars