Z3517967757

Z3517967757
Clinical data
Other names	Z7757, YEQ
Drug class	Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist
ATC code	None;
Identifiers
	IUPAC name 4-[1-(1-pyrimidin-2-ylethyl)piperidin-3-yl]phenol;
CAS Number	2817502-85-3 ;
PubChem CID	167949972;
ChemSpider	132760262;
PDB ligand	YEQ (PDBe, RCSB PDB);
Chemical and physical data
Formula	C17H21N3O
Molar mass	283.375 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=NC=CC=N1)N2CCCC(C2)C3=CC=C(C=C3)O;
	InChI InChI=1S/C17H21N3O/c1-13(17-18-9-3-10-19-17)20-11-2-4-15(12-20)14-5-7-16(21)8-6-14/h3,5-10,13,15,21H,2,4,11-12H2,1H3; Key:JDCMEPNJYDYSCB-UHFFFAOYSA-N;

Z3517967757, or simply Z7757, is a 3-phenylpiperidine derivative which acts as an agonist at the 5-HT₂ family of serotonin receptors, first reported in 2024. It can also be viewed as a ring-restrained phenethylamine.^[1] It has strongest activity at the 5-HT_2A receptor and lower affinity at the 5-HT_2B and 5-HT_2C receptors. However, it has been reported to have excellent selectivity for the 5-HT_2A receptor, with no agonistic activity at the 5-HT_2B and 5-HT_2C receptors.^[1] The drug was developed using in silico modelling to dock a large library of compounds against a 5-HT_2A receptor model generated by the artificial intelligence program AlphaFold, and then synthesised and tested in the laboratory to confirm activity. It has two stereogenic centers and four possible isomers,^[2]^[3]^[4] and was docked to the 5-HT_2A receptor as the (1R,3R) enantiomer YEQ.^[5]