IHCH-7086

Drug classNon-hallucinogenic serotonin 5-HT_2A receptor agonist

CAS Number

• 2957888-70-7 ^Y

PubChem CID

• 162421364

ChemSpider

• 133324800

IHCH-7086

Clinical data
Drug class	Non-hallucinogenic serotonin 5-HT2A receptor agonist
Identifiers
IUPAC name (6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-8-[3-(2-methoxyphenyl)propyl]-3-methyl-1H-Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
CAS Number	2957888-70-7 Y
PubChem CID	162421364
ChemSpider	133324800
Chemical and physical data
Formula	C24H31N3O
Molar mass	377.532 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(CCN1[C@]2([H])[C@@]3([H])CN(CCCC4=CC=CC=C4OC)CC2)C5=C1C3=CC=C5
InChI InChI=1S/C24H31N3O/c1-25-15-16-27-21-12-14-26(13-6-8-18-7-3-4-11-23(18)28-2)17-20(21)19-9-5-10-22(25)24(19)27/h3-5,7,9-11,20-21H,6,8,12-17H2,1-2H3/t20-,21-/m0/s1 Key:WFYFRJAKNJVZMP-SFTDATJTSA-N

IHCH-7086 is a non-hallucinogenic serotonin 5-HT_2A receptor biased agonist of the pyridopyrroloquinoxaline family. It was derived via structural simplification of the serotonin 5-HT_2A receptor antagonist and atypical antipsychotic lumateperone. The drug produces antidepressant-like effects but not psychedelic-like effects in rodents. Other related compounds include IHCH-7079, which is a non-hallucinogenic serotonin 5-HT_2A receptor biased agonist similarly, and IHCH-7113, which produces the head-twitch response in rodents and hence would be expected to be hallucinogenic in humans.^[1][2][3]