Galectine-3

LGALS3
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3, 3AYA, 3AYC, 3AYD, 3AYE, 3T1L, 3T1M, 3ZSJ, 3ZSK, 3ZSL, 3ZSM, 4BLI, 4BLJ, 4BM8, 4JC1, 4JCK, 4LBJ, 4LBK, 4LBL, 4LBM, 4LBN, 4LBO, 4R9A, 4R9B, 4R9C, 4R9D, 4RL7, 4XBN, 5H9R, 5H9P
Identifiants
Alias	LGALS3
IDs externes	OMIM: 153619 MGI: 96778 HomoloGene: 37608 GeneCards: LGALS3
Position du gène (humain)
Chr.	Chromosome 14 humain
Fin	55,145,423 bp
Position du gène (souris)
Chr.	Chromosome 14 (souris)
Fin	47,623,617 bp
Expression génique
	Fortement exprimé dans
	mucosa of colon; ; palpebral conjunctiva; ; mucosa of sigmoid colon; ; cellule épithéliale bronchiale; ; nasal epithelium; ; Caduque basale; ; mucosa of ileum; ; muqueuse jéjunale; ; mucosa of transverse colon; ; liquide amniotique;
	Fortement exprimé dans
	skin of external ear; ; left colon; ; Caduque basale; ; transitional epithelium of urinary bladder; ; calvaria; ; granulocyte; ; gastrula; ; stroma of bone marrow; ; lèvre; ; skin of abdomen;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; chemoattractant activity; IgE binding; laminin binding; liaison de carbohydrate; liaison ARN; oligosaccharide binding; protein phosphatase inhibitor activity; protein phosphatase binding;
Composant cellulaire	cytoplasme; membrane; matrice extracellulaire; membrane plasmique; synapse immunologique; membrane mitochondriale interne; spliceosomal complex; exosome; noyau; milieu extracellulaire; secretory granule membrane; ficolin-1-rich granule membrane; galectin complex; région extracellulaire; surface cellulaire; collagen-containing extracellular matrix;
Processus biologique	negative regulation of endocytosis; différenciation cellulaire; regulation of T cell proliferation; negative regulation of immunological synapse formation; epithelial cell differentiation; monocyte chemotaxis; processus du système immunitaire; mRNA processing; eosinophil chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of mononuclear cell migration; neutrophil chemotaxis; negative regulation of T cell receptor signaling pathway; mononuclear cell migration; positive regulation of calcium ion import; macrophage chemotaxis; regulation of T cell apoptotic process; épissage; positive regulation of dendritic cell differentiation; regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive chemotaxis; système immunitaire inné; neutrophil degranulation; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of myeloid cell differentiation; positive regulation of protein homodimerization activity; positive regulation of protein localization to plasma membrane; negative regulation of protein tyrosine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologues
	3958
	16854
	ENSG00000131981
	ENSMUSG00000050335
	P17931
	P16110
	NM_001177388; NM_002306; NM_001357678
	NM_001145953; NM_010705
	NP_002297; NP_001344607
	n/a
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasLGALS3

IDs externesOMIM: 153619 MGI: 96778 HomoloGene: 37608 GeneCards: LGALS3

Chr.Chromosome 14 humain^[1]

La galectine-3 (Gal-3) est l'une des galectines, ces dernières étant des lectines, glycoprotéines intervenant dans différents processus biologiques. Elle se fixe sur le bêta-galactoside et est sécrétée par les macrophages. Son gène est le LGALS3 situé sur le chromosome 14 humain.

[1]

[2]

[3]

[4]

Galectine-3

Voir aussi

Notes et références

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