2023 Nigerian Senate elections in Ondo State

In the previous Senate elections, only one of the three incumbent senators were returned as Robert Ajayi Boroffice (APC-Central) was re-elected while Tayo Alasoadura (APC-North) and Yele Omogunwa (APC-South) were defeated. Patrick Ayo Akinyelure defeated Alasoadura with 33% of the vote while PDP challenger Nicholas Tofowomo unseated Omogunwa with 43%; in the central seat, Boroffice was re-elected with 30%. These results were a part of the continuation of the state's continued competitiveness as four parties won at least one House of Representatives seat, the APC won a majority in the state House of Assembly, and Buhari narrowly won the state in the presidential election. In 2020, incumbent Governor Rotimi Akeredolu held the governorship.

The Ondo Central Senatorial District covers the local government areas of Akure North, Akure South, Idanre, Ifedore, Ondo East, and Ondo West. Incumbent Patrick Ayo Akinyelure (PDP), who was elected with 33.1% of the vote in 2019, sought re-election but lost renomination.

The Ondo North Senatorial District covers the local government areas of Akoko North-East, Akoko North-West, Akoko South-East, Akoko South-West, Ose, and Owo. Incumbent Robert Ajayi Boroffice (APC) was elected with 30.3% of the vote in 2019. In April 2022, Boroffice announced that he would run for president instead of seeking re-election;^[11] however, Amosun withdrew on the date of the APC primary in favour of eventual nominee Bola Tinubu.^[12]