| 2026 Game Log: 73–65 (Home: 41–28; Road: 32–37) |
March/April: 19–11 (Home: 10–6; Road: 9–5)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 1 | March 26 | Tigers | 2–8 | Skubal (1–0) | Pivetta (0–1) | — | 45,673 | 0–1 | L1 |
| 2 | March 27 | Tigers | 2–5 | De Jesus (1–0) | Estrada (0–1) | Jansen (1) | 44,896 | 0–2 | L2 |
| 3 | March 28 | Tigers | 3–0 | Vásquez (1–0) | Flaherty (0–1) | Miller (1) | 44,368 | 1–2 | W1 |
| 4 | March 30 | Giants | 2–3 | Roupp (1–0) | Buehler (0–1) | Walker (1) | 43,611 | 1–3 | L1 |
| 5 | March 31 | Giants | 3–9 | Webb (1–1) | Márquez (0–1) | — | 41,891 | 1–4 | L2 |
| 6 | April 1 | Giants | 7–1 | Pivetta (1–1) | Houser (0–1) | Miller (2) | 41,491 | 2–4 | W1 |
| 7 | April 3 | @ Red Sox | 2–5 | Gray (1–0) | King (0–1) | Chapman (2) | 36,233 | 2–5 | L1 |
| 8 | April 4 | @ Red Sox | 3–2 | Morejón (1–0) | Chapman (0–1) | Miller (3) | 36,405 | 3–5 | W1 |
| 9 | April 5 | @ Red Sox | 8–6 | Estrada (1–1) | Uberstine (0–1) | Miller (4) | 29,240 | 4–5 | W2 |
| 10 | April 6 | @ Pirates | 5–0 | Márquez (1–1) | Chandler (0–1) | — | 8,446 | 5–5 | W3 |
| 11 | April 7 | @ Pirates | 1–7 | Skenes (2–1) | Pivetta (1–2) | — | 9,061 | 5–6 | L1 |
| 12 | April 8 | @ Pirates | 8–2 | King (1–1) | Lawrence (0–1) | — | 10,046 | 6–6 | W1 |
| 13 | April 9 | Rockies | 7–3 (12) | Morgan (1–0) | Bellozo (0–1) | — | 41,390 | 7–6 | W2 |
| 14 | April 10 | Rockies | 5–2 | Miller (1–0) | Mejía (0–2) | — | 42,454 | 8–6 | W3 |
| 15 | April 11 | Rockies | 9–5 | Márquez (2–1) | Feltner (1–1) | Adam (1) | 42,318 | 9–6 | W4 |
| 16 | April 12 | Rockies | 7–2 | Morgan (2–0) | Herget (0–1) | — | 39,786 | 10–6 | W5 |
| 17 | April 14 | Mariners | 4–1 | King (2–1) | Woo (0–2) | Miller (5) | 38,152 | 11–6 | W6 |
| 18 | April 15 | Mariners | 7–6 | Jacob (1–0) | Muñoz (2–2) | — | 46,095 | 12–6 | W7 |
| 19 | April 16 | Mariners | 5–2 | Buehler (1–1) | Castillo (0–1) | Miller (6) | 39,008 | 13–6 | W8 |
| 20 | April 17 | @ Angels | 0–8 | Soriano (5–0) | Waldron (0–1) | — | 44,551 | 13–7 | L1 |
| 21 | April 18 | @ Angels | 4–1 | Morejón (2–0) | Zeferjahn (1–1) | Miller (7) | 44,279 | 14–7 | W1 |
| 22 | April 19 | @ Angels | 2–1 | King (3–1) | Ureña (0–2) | Miller (8) | 44,560 | 15–7 | W2 |
| 23 | April 21 | @ Rockies | 1–0 | Vásquez (2–0) | Dollander (2–2) | Morejón (1) | 15,672 | 16–7 | W3 |
| 24 | April 22 | @ Rockies | 3–8 | Sugano (2–1) | Buehler (1–2) | — | 18,114 | 16–8 | L1 |
| 25 | April 23 | @ Rockies | 10–8 | Marinaccio (1–0) | Vodnik (0–2) | Miller (9) | 25,973 | 17–8 | W1 |
| 26 | April 25 | @ Diamondbacks* | 6–4 | Márquez (3–1) | Clarke (1–1) | Miller (10) | 19,630 | 18–8 | W2 |
| 27 | April 26 | @ Diamondbacks* | 7–12 | Thompson (2–0) | Rodríguez (0–1) | — | 19,671 | 18–9 | L1 |
| 28 | April 27 | Cubs | 9–7 | Vásquez (3–0) | Brown (1–1) | — | 41,478 | 19–9 | W1 |
| 29 | April 28 | Cubs | 3–8 | Cabrera (3–0) | Hart (0–1) | — | 40,106 | 19–10 | L1 |
| 30 | April 29 | Cubs | 4–5 | Taillon (2–1) | Morejón (2–1) | Milner (1) | 36,513 | 19–11 | L2 |
| *April 25 and 26 games played at Estadio Alfredo Harp Helú in Mexico City, Mexico |
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May: 13–15 (Home: 6–10; Road: 7–5)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 31 | May 1 | White Sox | 2–8 | Schultz (2–1) | Márquez (3–2) | — | 43,638 | 19–12 | L3 |
| 32 | May 2 | White Sox | 0–4 | Burke (2–2) | King (3–2) | Domínguez (8) | 42,758 | 19–13 | L4 |
| 33 | May 3 | White Sox | 4–3 | Adam (1–0) | Davis (0–1) | Miller (11) | 40,171 | 20–13 | W1 |
| 34 | May 4 | @ Giants | 2–3 | McDonald (1–0) | Vásquez (3–1) | Kilian (1) | 33,097 | 20–14 | L1 |
| 35 | May 5 | @ Giants | 10–5 | Buehler (2–2) | Webb (2–4) | — | 38,275 | 21–14 | W1 |
| 36 | May 6 | @ Giants | 5–1 | Waldron (1–1) | Houser (0–4) | — | 34,181 | 22–14 | W2 |
| 37 | May 7 | Cardinals | 1–2 | Liberatore (2–1) | Rodríguez (0–2) | O'Brien (11) | 44,966 | 22–15 | L1 |
| 38 | May 8 | Cardinals | 0–6 | McGreevy (3–2) | Canning (0–1) | — | 40,442 | 22–16 | L2 |
| 39 | May 9 | Cardinals | 4–2 | Vásquez (4–1) | May (3–4) | Miller (12) | 41,559 | 23–16 | W1 |
| 40 | May 10 | Cardinals | 3–2 (10) | Morejón (3–1) | Graceffo (2–1) | — | 39,795 | 24–16 | W2 |
| 41 | May 12 | @ Brewers | 4–6 | Sproat (1–2) | Waldron (1–2) | Uribe (4) | 25,372 | 24–17 | L1 |
| 42 | May 13 | @ Brewers | 3–1 | Adam (2–0) | Uribe (2–2) | Miller (13) | 28,683 | 25–17 | W1 |
| 43 | May 14 | @ Brewers | 1–7 | Harrison (4–1) | Canning (0–2) | — | 34,862 | 25–18 | L1 |
| 44 | May 15 | @ Mariners | 2–0 | Vásquez (5–1) | Hancock (3–2) | Miller (14) | 43,349 | 26–18 | W1 |
| 45 | May 16 | @ Mariners | 7–4 | Buehler (3–2) | Gilbert (2–4) | Estrada (1) | 44,207 | 27–18 | W2 |
| 46 | May 17 | @ Mariners | 8–3 | Giolito (1–0) | Kirby (5–3) | — | 40,365 | 28–18 | W3 |
| 47 | May 18 | Dodgers | 1–0 | King (4–2) | Yamamoto (3–4) | Miller (15) | 40,882 | 29–18 | W4 |
| 48 | May 19 | Dodgers | 4–5 | Scott (1–1) | Miller (1–1) | Klein (1) | 39,788 | 29–19 | L1 |
| 49 | May 20 | Dodgers | 0–4 | Ohtani (4–2) | Vásquez (5–2) | — | 41,888 | 29–20 | L2 |
| 50 | May 22 | Athletics | 7–3 | Morejón (4–1) | Springs (3–5) | — | 41,180 | 30–20 | W1 |
| 51 | May 23 | Athletics | 2–0 | Giolito (2–0) | Ginn (2–3) | Miller (16) | 42,616 | 31–20 | W2 |
| 52 | May 24 | Athletics | 2–5 | Lopez (4–2) | King (4–3) | Barlow (1) | 41,799 | 31–21 | L1 |
| 53 | May 25 | Phillies | 0–3 | Luzardo (4–4) | Canning (0–3) | Durán (10) | 41,293 | 31–22 | L2 |
| 54 | May 26 | Phillies | 3–4 | Nola (3–4) | Vásquez (5–3) | Durán (11) | 40,399 | 31–23 | L3 |
| 55 | May 27 | Phillies | 0–3 | Sánchez (6–2) | Buehler (3–3) | Alvarado (1) | 37,426 | 31–24 | L4 |
| 56 | May 29 | @ Nationals | 7–5 | Estrada (2–1) | Parker (2–2) | Miller (17) | 26,529 | 32–24 | W1 |
| 57 | May 30 | @ Nationals | 4–9 | Lord (3–0) | King (4–4) | Beeter (3) | 30,765 | 32–25 | L1 |
| 58 | May 31 | @ Nationals | 2–4 | Littell (5–4) | Canning (0–4) | Beeter (4) | 24,050 | 32–26 | L2 |
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June: 11–15 (Home: 7–5; Road: 4–10)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 59 | June 2 | @ Phillies | 2–3 | Alvarado (2–1) | Estrada (2–2) | Durán (13) | 38,763 | 32–27 | L3 |
| 60 | June 3 | @ Phillies | 2–3 | Sánchez (7–2) | Adam (2–1) | Durán (14) | 40,453 | 32–28 | L4 |
| 61 | June 4 | @ Phillies | 4–6 | Wheeler (5–1) | Giolito (2–1) | — | 37,812 | 32–29 | L5 |
| 62 | June 5 | Mets | 0–5 | Scott (2–0) | King (4–5) | — | 42,159 | 32–30 | L6 |
| 63 | June 6 | Mets | 3–2 | Rodríguez (1–2) | Warren (1–2) | Miller (18) | 40,770 | 33–30 | W1 |
| 64 | June 7 | Mets | 3–7 | Manaea (1–1) | Vásquez (5–4) | — | 41,159 | 33–31 | L1 |
| 65 | June 8 | Reds | 6–2 | Morejón (5–1) | Abbott (4–4) | — | 37,223 | 34–31 | W1 |
| 66 | June 9 | Reds | 3–5 (11) | Antone (1–0) | Matsui (0–1) | Maxwell (1) | 40,469 | 34–32 | L1 |
| 67 | June 10 | Reds | 5–4 | Peralta (1–0) | Petty (0–1) | — | 37,393 | 35–32 | W1 |
| 68 | June 12 | @ Orioles | 3–7 | Baz (4–6) | Canning (0–5) | — | 25,458 | 35–33 | L1 |
| 69 | June 13 | @ Orioles | 9–3 | Vásquez (6–4) | Gibson (1–2) | — | 25,722 | 36–33 | W1 |
| 70 | June 14 | @ Orioles | 5–2 | Buehler (4–3) | Rogers (3–7) | Miller (19) | 20,611 | 37–33 | W2 |
| 71 | June 15 | @ Cardinals | 0–3 | May (5–6) | Giolito (2–2) | — | 26,973 | 37–34 | L1 |
| 72 | June 16 | @ Cardinals | 2–3 | Pallante (8–4) | King (4–6) | O'Brien (18) | 29,604 | 37–35 | L2 |
| 73 | June 17 | @ Cardinals | 6–1 | Canning (1–5) | Leahy (5–4) | — | 29,859 | 38–35 | W1 |
| 74 | June 19 | @ Rangers | 7–9 | deGrom (6–4) | Vásquez (6–5) | Latz (13) | 33,406 | 38–36 | L1 |
| 75 | June 20 | @ Rangers | 6–4 (10) | Morejón (6–1) | Ross (0–1) | Miller (20) | 35,383 | 39–36 | W1 |
| 76 | June 21 | @ Rangers | 3–4 | Eovaldi (7–7) | Giolito (2–3) | Junis (5) | 36,311 | 39–37 | L1 |
| 77 | June 22 | Braves | 1–0 | King (5–6) | Holmes (4–4) | Miller (21) | 42,572 | 40–37 | W1 |
| 78 | June 23 | Braves | 7–6 (10) | Miller (2–1) | Iglesias (0–2) | — | 41,379 | 41–37 | W2 |
| 79 | June 24 | Braves | 5–2 | Sears (1–0) | Pérez (6–4) | Adam (2) | 40,183 | 42–37 | W3 |
| 80 | June 26 | Dodgers | 7–1 | Buehler (5–3) | Sasaki (3–5) | — | 43,153 | 43–37 | W4 |
| 81 | June 27 | Dodgers | 3–15 | Yamamoto (8–5) | Vásquez (6–6) | — | 45,159 | 43–38 | L1 |
| 82 | June 28 | Dodgers | 2–4 | Sheehan (4–5) | King (5–7) | Henriquez (1) | 41,189 | 43–39 | L2 |
| 83 | June 29 | @ Cubs | 2–3 | Thornton (3–2) | Adam (2–2) | — | 37,607 | 43–40 | L3 |
| 84 | June 30 | @ Cubs | 7–9 | Boyd (3–1) | Sears (1–1) | Rolison (1) | 36,279 | 43–41 | L4 |
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July: 13–13 (Home: 7–4; Road: 6–9)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 85 | July 1 | @ Cubs | 3–23 | Rea (6–5) | Buehler (5–4) | Wicks (2) | 37,311 | 43–42 | L5 |
| 86 | July 2 | @ Dodgers | 7–12 | Klein (3–2) | Peralta (1–1) | — | 54,081 | 43–43 | L6 |
| 87 | July 3 | @ Dodgers | 3–4 | Hurt (3–1) | Morejón (6–2) | Scott (12) | 49,578 | 43–44 | L7 |
| 88 | July 4 | @ Dodgers | 0–3 | Yamamoto (9–5) | Canning (1–6) | Klein (2) | 52,284 | 43–45 | L8 |
| 89 | July 5 | @ Dodgers | 5–2 | Sears (2–1) | Sheehan (4–6) | Miller (22) | 46,506 | 44–45 | W1 |
| 90 | July 6 | Diamondbacks | 0–8 | Pfaadt (2–1) | Buehler (5–5) | — | 38,204 | 44–46 | L1 |
| 91 | July 7 | Diamondbacks | 4–1 | Márquez (4–2) | Gallen (3–9) | Miller (23) | 40,223 | 45–46 | W1 |
| 92 | July 8 | Diamondbacks | 10–4 | King (6–7) | Cabrera (0–2) | — | 39,423 | 46–46 | W2 |
| 93 | July 9 | Diamondbacks | 1–3 | Kelly (7–8) | Canning (1–7) | Sewald (21) | 39,270 | 46–47 | L1 |
| 94 | July 10 | Blue Jays | 3–5 | Fluharty (4–0) | Sears (2–2) | Varland (19) | 41,886 | 46–48 | L2 |
| 95 | July 11 | Blue Jays | 8–7 | Rodríguez (2–2) | Fluharty (4–1) | Miller (24) | 40,561 | 47–48 | W1 |
| 96 | July 12 | Blue Jays | 5–4 | Morejón (7–2) | Hoffman (5–6) | Miller (25) | 41,675 | 48–48 | W2 |
| 96th All-Star Game: Philadelphia, PA |
| 97 | July 17 | @ Royals | 6–7 (10) | Erceg (4–3) | Hart (0–2) | — | 25,884 | 48–49 | L1 |
| 98 | July 18 | @ Royals | 1–6 | Lynch IV (3–2) | Canning (1–8) | — | 23,347 | 48–50 | L2 |
| 99 | July 19 | @ Royals | 19–2 | Matsui (1–1) | Cameron (5–8) | — | 18,383 | 49–50 | W1 |
| 100 | July 20 | @ Braves | 2–3 | Elder (6–6) | Sears (2–3) | Mederos (1) | 31,263 | 49–51 | L1 |
| 101 | July 21 | @ Braves | 8–3 | Buehler (6–5) | López (4–3) | — | 31,870 | 50–51 | W1 |
| 102 | July 22 | @ Braves | 6–7 | Lee (5–0) | Peralta (1–2) | Iglesias (20) | 33,766 | 50–52 | L1 |
| 103 | July 23 | @ Braves | 5–6 | Sale (11–6) | Canning (1–9) | Iglesias (21) | 29,441 | 50–53 | L2 |
| 104 | July 24 | @ Marlins | 4–2 | Morejón (8–2) | Zuber (0–1) | Miller (26) | 16,151 | 51–53 | W1 |
| 105 | July 25 | @ Marlins | 7–2 | Sears (3–3) | Pérez (5–8) | — | 22,319 | 52–53 | W2 |
| 106 | July 26 | @ Marlins | 5–3 | Peralta (2–2) | Bachar (1–2) | Miller (27) | 21,675 | 53–53 | W3 |
| 107 | July 28 | Rockies | 8–7 | Miller (3–1) | Herget (0–4) | — | 42,433 | 54–53 | W4 |
| 108 | July 29 | Rockies | 3–1 | Canning (2–9) | Hughes (0–3) | Miller (28) | 40,714 | 55–53 | W5 |
| 109 | July 30 | Giants | 1–4 | Ray (10–6) | Sears (3–4) | Miller (4) | 42,758 | 55–54 | L1 |
| 110 | July 31 | Giants | 7–0 | Matsui (2–1) | Whisenhunt (2–2) | Márquez (1) | 44,057 | 56–54 | W1 |
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August: 17–11 (Home: 11–3; Road: 6–8)
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Streak |
| 111 | August 1 | Giants | 6–5 | Miller (4–1) | Smith (0–3) | — | 43,766 | 57–54 | W2 |
| 112 | August 2 | Giants | 5–4 | Canning (3–9) | Roupp (7–10) | Morejón (2) | 43,856 | 58–54 | W3 |
| 113 | August 3 | @ Diamondbacks | 1–5 | Pfaadt (6–1) | King (6–8) | — | 22,008 | 58–55 | L1 |
| 114 | August 4 | @ Diamondbacks | 9–4 | Vásquez (7–6) | Rodríguez (10–4) | — | 20,839 | 59–55 | W1 |
| 115 | August 5 | @ Diamondbacks | 4–10 | Bratt (1–1) | Mize (4–7) | — | 17,559 | 59–56 | L1 |
| 116 | August 6 | @ Diamondbacks | 5–1 | Rodríguez (3–2) | Drake (0–1) | — | 21,884 | 60–56 | W1 |
| 117 | August 7 | Astros | 3–6 | Abreu (4–3) | Ray (10–7) | Hader (16) | 40,958 | 60–57 | L1 |
| 118 | August 8 | Astros | 3–2 | King (7–8) | Lambert (8–6) | Miller (29) | 41,937 | 61–57 | W1 |
| 119 | August 9 | Astros | 7–2 | Vásquez (8–6) | Javier (1–3) | — | 40,160 | 62–57 | W2 |
| 120 | August 10 | Brewers | 3–2 | Matsui (3–1) | Henderson (6–2) | Miller (30) | 40,323 | 63–57 | W3 |
| 121 | August 11 | Brewers | 11–2 | Buehler (7–5) | Harrison (9–3) | — | 40,534 | 64–57 | W4 |
| 122 | August 12 | Brewers | 4–3 (11) | Morejón (9–2) | Senzatela (9–4) | — | 36,072 | 65–57 | W5 |
| 123 | August 14 | @ Guardians | 7–5 | King (8–8) | Williams (11–7) | Rodríguez (1) | 35,726 | 66–57 | W6 |
| 124 | August 15 | @ Guardians | 1–6 | Cantillo (9–7) | Hart (0–3) | — | 35,153 | 66–58 | L1 |
| 125 | August 16 | @ Guardians | 5–0 | Mize (5–7) | Bibee (4–13) | — | 24,708 | 67–58 | W1 |
| 126 | August 17 | @ Mets | 1–2 | McLean (9–8) | Buehler (7–6) | Duarte (2) | 27,842 | 67–59 | L1 |
| 127 | August 18 | @ Mets | 5–2 | Ray (11–7) | Thornton (3–4) | Miller (31) | 35,508 | 68–59 | W1 |
| 128 | August 19 | @ Mets | 2–4 | Lavender (1–0) | King (8–9) | Senga (4) | 26,195 | 68–60 | L1 |
| 129 | August 21 | Twins | 6–2 | Vásquez (9–6) | Prielipp (3–7) | — | 44,293 | 69–60 | W1 |
| 130 | August 22 | Twins | 7–5 | Canning (4–9) | Morris (4–5) | Miller (32) | 41,484 | 70–60 | W2 |
| 131 | August 23 | Twins | 8–1 | Buehler (8–6) | Funderburk (3–2) | — | 40,103 | 71–60 | W3 |
| 132 | August 24 | Pirates | 2–3 (12) | Yates (2–5) | Estrada (2–3) | Ramírez (2) | 40,447 | 71–61 | L1 |
| 133 | August 25 | Pirates | 0–1 | Soto (6–4) | Miller (4–2) | Montgomery (6) | 40,709 | 71–62 | L2 |
| 134 | August 26 | Pirates | 3–0 | Vásquez (10–6) | Chandler (6–9) | Rodríguez (2) | 40,413 | 72–62 | W1 |
| 135 | August 28 | @ Rays | 4–9 | McClanahan (10–6) | Mize (5–8) | — | 16,470 | 72–63 | L1 |
| 136 | August 29 | @ Rays | 6–7 | Kelly (6–3) | Rodríguez (3–3) | Baker (39) | 25,621 | 72–64 | L2 |
| 137 | August 30 | @ Rays | 4–5 (11) | Wells (3–2) | Morgan (2–1) | — | 19,576 | 72–65 | L3 |
| 138 | August 31 | @ Reds | 5–0 | King (9–9) | Singer (5–13) | — | 16,162 | 73–65 | W1 |
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September: 0–0 (Home: 0–0; Road: 0–0)
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Legend: = Win = Loss = Postponement Bold = Padres team member |