6-Fluoro-AMT
Chemical compound
From Wikipedia, the free encyclopedia
6-Fluoro-AMT, or 6-fluoro-αMT, also known as 6-fluoro-α-methyltryptamine, is a psychedelic drug of the tryptamine family related to α-methyltryptamine (AMT) and 5-MeO-AMT.[1][2]
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| Other names | 6-Fluoro-AMT; 6-Fluoro-αMT; 6F-AMT; 6F-αMT; 6-F-AMT; 6-F-αMT; 6-Fluoro-α-methyltryptamine |
| Routes of administration | Oral |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Formula | C11H13FN2 |
| Molar mass | 192.237 g·mol−1 |
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Use and effects
6-Fluoro-AMT was allegedly manufactured and sold from the laboratory operated by Leonard Pickard and Gordon Todd Skinner, who described 6-fluoro-AMT as "a beast".[1] In interviews, Skinner stated that he first began to experiment with 6-fluoro-AMT in the early 1980s by giving it to high school friends.[2] Their experiences made him cautious about the appropriate doses, which he said ranged from 25 to 75 mg (Skinner weighed about 250 lbs at the time of his own bioassay).[2] Skinner said that 6-fluoro-AMT is a long-lasting psychedelic with more time distortion and that it was enhanced by combination with ALD-52.[2]
Interactions
Pharmacology
Pharmacodynamics
Animal tests showed the drug to be somewhat less potent in terms of pharmacological activity than AMT or 5-fluoro-AMT.[3] It produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.[4][5][6] Its IC50 for monoamine oxidase A (MAO-A) inhibition is 580 to 1,800 nM, compared to 180 to 450 nM for 5-fluoro-AMT and 380 nM for AMT.[5][7][8]
Chemistry
Analogues
Analogues of 6-fluoro-AMT include α-methyltryptamine (AMT), 5-fluoro-AMT, 5-chloro-AMT, 5-fluoro-AET, 5-chloro-AET, 6-fluoro-DMT, 6-fluoro-DET, 6-methyl-DMT, 6-MeO-DMT, 6-hydroxy-DMT, 7-chloro-AMT, and O-4310 (1-isopropyl-6-fluoro-4-HO-DMT), among others.
History
6-Fluoro-AMT was first described in the scientific literature, by Asher Kalir and Stephen Szara, by at least 1963.[3]
Society and culture
Legal status
Canada
6-Fluoro-AMT is not an explicitly nor implicitly controlled substance in Canada as of 2025.[9]
United States
6-Fluoro-AMT is not an explicitly controlled substance in the United States.[10] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.