ANP32E

ANP32E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CAY, 4NFT
Identifiers
Aliases	ANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDs	OMIM: 609611; MGI: 1913721; HomoloGene: 137403; GeneCards: ANP32E; OMA:ANP32E - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,236,156 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,854,702 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; caput epididymis; ; corpus epididymis; ; dorsal motor nucleus of vagus nerve; ; ventricular zone; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; tail of epididymis; ; Epithelium of choroid plexus; ; gingival epithelium;
	Top expressed in
	tail of embryo; ; neural layer of retina; ; genital tubercle; ; otic vesicle; ; pineal gland; ; otic placode; ; cumulus cell; ; saccule; ; ventricular zone; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone binding; phosphatase inhibitor activity;
Cellular component	cytoplasm; nucleus; Swr1 complex; cytoplasmic vesicle;
Biological process	negative regulation of catalytic activity; histone exchange; nucleosome assembly; nucleocytoplasmic transport; regulation of apoptotic process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	81611
	66471
	ENSG00000143401
	ENSMUSG00000015749
	Q9BTT0
	P97822
	NM_001136478; NM_001136479; NM_001280559; NM_001280560; NM_030920
	NM_001253757; NM_001253758; NM_023210
	NP_001129950; NP_001129951; NP_001267488; NP_001267489; NP_112182
	NP_001240686; NP_001240687; NP_075699
	Wikidata
View/Edit Human	View/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.^[5]^[6] The ANP32E gene is located on chromosome 1q22.^[5] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.^[7] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis^[8] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.^[9]