Asymbescaline
Pharmaceutical compound
From Wikipedia, the free encyclopedia
Asymbescaline (ASB), also known as 3,4-diethoxy-5-methoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2][3] It is the analogue of mescaline in which the methoxy groups at the 3 and 4 positions have been replaced with ethoxy groups.[1][2][3]
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| Other names | ASB; 3,4-Diethoxy-5-methoxyphenethylamine |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Onset of action | Peak: 2 hours[1] |
| Duration of action | 10–15 hours[1] |
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| Formula | C13H21NO3 |
| Molar mass | 239.315 g·mol−1 |
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Use and effects
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists asymbescaline's dose as 200 to 280 mg orally and its duration as 10 to 15 hours.[1][2][3] The time to peak was approximately 2 hours.[1]
The effects of asymbescaline were reported to include a lack of visual and interpretive richness, few if any of the "open interactions" of other psychedelics like 2C-B or LSD, daydreaming, and visions while trying to sleep, and "some negative side".[1] One report described it as a "sort of gentler sister of mescaline", but with a tendency to emphasize the negative such as sadness and struggle.[1] Another report described it as "like being in a corridor outside the lighted halls where a beautiful mescaline experience is taking place, sensing the light from behind a grey door, and not being able to find my way in from the dusky underside passageways".[1] Physical and other side effects included some "body load, physical weirdness, heart rate changes, and insomnia and sleep disruption.[1] Per Shulgin, the consensus from over a half dozen tests was that there was not enough value with the drug to offset its body load.[1]
Interactions
Chemistry
Synthesis
The chemical synthesis of asymbescaline has been described.[1]
Analogues
Analogues of asymbescaline include mescaline, escaline, metaescaline, symbescaline, and trisescaline (trescaline), among others.[1][2][3]
History
Asymbescaline was first described in the scientific literature by George S. Grace in 1934.[4] Subsequently, it was described in greater detail by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1]
Society and culture
Legal status
Canada
Asymbescaline is not a controlled substance in Canada as of 2025.[5]