Filaminast

ATC code

• None

Legal status

• Development terminated

CAS Number

• 141184-34-1

PubChem CID

• 9578243

Filaminast

Clinical data
ATC code	None
Legal status
Legal status	Development terminated
Identifiers
IUPAC name [(E)-1-(3-Cyclopentyloxy-4-methoxyphenyl)ethylideneamino] carbamate
CAS Number	141184-34-1
PubChem CID	9578243
DrugBank	DB02660
ChemSpider	7852607
UNII	CDD69JC61J
KEGG	D04185
CompTox Dashboard (EPA)	DTXSID80869910
Chemical and physical data
Formula	C15H20N2O4
Molar mass	292.335 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=NOC(=O)N)C1=CC(=C(C=C1)OC)OC2CCCC2

Filaminast (code name WAY-PDA 641)^[1] was a drug candidate developed by Wyeth-Ayerst.^{[2]: Table 2} It is a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts.^{[3][4]: 668, 678} It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.^[4]: 678