Tofogliflozin

Other namesCSG452

ATC code

• None

Legal status

• Investigational

CAS Number

• 1201913-82-7
  903565-83-3 (anhydrous)

Tofogliflozin monohydrate

Clinical data
Other names	CSG452
ATC code	None
Legal status
Legal status	Investigational
Identifiers
IUPAC name (1S,3'R,4'S,5'S,6'R)-6-(4-Ethylbenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[2-benzofuran-1,2'-pyran]-3',4',5'-triol hydrate (1:1)
CAS Number	1201913-82-7 903565-83-3 (anhydrous)
PubChem CID	46908928
ChemSpider	28527871
UNII	P8DD8KX4O4
KEGG	D09978
ChEMBL	ChEMBL2105711
CompTox Dashboard (EPA)	DTXSID70152722
Chemical and physical data
Formula	C22H28O7
Molar mass	404.459 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCc1ccc(cc1)Cc2ccc3c(c2)[C@]4([C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)OC3.O
InChI InChI=1S/C22H26O6.H2O/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22;/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3;1H2/t18-,19-,20+,21-,22+;/m1./s1 Key:ZXOCGDDVNPDRIW-NHFZGCSJSA-N

Tofogliflozin (INN,^[1]: 88 USAN, codenamed CSG452) is a drug developed for the treatment of diabetes mellitus type 2 and was originally co-developed by Chugai Pharma in collaboration with Kowa and Sanofi.^[2] It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. As of 2014, tofogliflozin was approved for use in Japan and is marketed under the brand names Apleway and Deberza.^[3][4] It has not been approved for use outside of Japan.^[5]