SMAD3

SMAD3
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Identifiants
Alias	SMAD3
IDs externes	OMIM: 603109 MGI: 1201674 HomoloGene: 55937 GeneCards: SMAD3
Position du gène (humain)
Chr.	Chromosome 15 humain
Fin	67,195,173 bp
Position du gène (souris)
Chr.	Chromosome 9 (souris)
Fin	63,665,276 bp
Expression génique
	Fortement exprimé dans
	tendon of biceps brachii; ; cartilage tissue; ; muscle de la cuisse; ; mucosa of esophagus; ; epithelium of colon; ; muscle gastrocnémien; ; jointure synoviale; ; Skeletal muscle tissue of biceps brachii; ; mucosa of urinary bladder; ; olfactory zone of nasal mucosa;
	Fortement exprimé dans
	tubercule génital; ; muscle temporal; ; muscle triceps brachial; ; molaire; ; cheville; ; muscle sterno-cléido-mastoïdien; ; tail of embryo; ; artère carotide interne; ; artère carotide externe; ; fosse;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison de phosphatase; DNA-binding transcription factor activity; R-SMAD binding; co-SMAD binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; liaison ion métal; RNA polymerase II cis-regulatory region sequence-specific DNA binding; liaison enzymatique; transforming growth factor beta receptor binding; protein homodimerization activity; collagen binding; zinc ion binding; liaison de chromatine; cis-regulatory region sequence-specific DNA binding; liaison protéique; double-stranded DNA binding; protein kinase binding; sequence-specific DNA binding; liaison ADN; bHLH transcription factor binding; ubiquitin binding; identical protein binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; beta-catenin binding; RNA polymerase II general transcription initiation factor activity; DEAD/H-box RNA helicase binding; mineralocorticoid receptor binding; glucocorticoid receptor binding; primary miRNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; SMAD binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coregulator activity;
Composant cellulaire	cytoplasme; noyau; heteromeric SMAD protein complex; SMAD protein complex; transcription regulator complex; receptor complex; membrane plasmique; intracellulaire; nucléoplasme; nuclear inner membrane; cytosol; complexe macromoléculaire;
Processus biologique	Somitogenèse; skeletal system development; ureteric bud development; endoderm development; regulation of transforming growth factor beta2 production; embryonic pattern specification; regulation of transcription by RNA polymerase II; negative regulation of osteoblast differentiation; heart looping; positive regulation of chondrocyte differentiation; positive regulation of alkaline phosphatase activity; positive regulation of interleukin-1 beta production; pericardium development; regulation of binding; negative regulation of wound healing; activation of cysteine-type endopeptidase activity involved in apoptotic process; transforming growth factor beta receptor signaling pathway; negative regulation of inflammatory response; positive regulation of positive chemotaxis; negative regulation of cell population proliferation; negative regulation of fat cell differentiation; cell-cell junction organization; regulation of transcription, DNA-templated; extrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; signal transduction involved in regulation of gene expression; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; nodal signaling pathway; régulation positive de la transcription dépendante de l'ADN; negative regulation of cell growth; regulation of immune response; positive regulation of transforming growth factor beta3 production; T cell activation; activin receptor signaling pathway; regulation of striated muscle tissue development; embryonic foregut morphogenesis; positive regulation of bone mineralization; cicatrisation; negative regulation of apoptotic process; positive regulation of extracellular matrix assembly; negative regulation of transcription by RNA polymerase II; positive regulation of epithelial to mesenchymal transition; mitigation of host defenses by virus; thyroid gland development; developmental growth; lens fiber cell differentiation; gastrulation; réponse immunitaire; osteoblast differentiation; primary miRNA processing; negative regulation of osteoblast proliferation; osteoblast development; embryonic cranial skeleton morphogenesis; transdifférenciation; paraxial mesoderm morphogenesis; response to hypoxia; positive regulation of cell migration; mesoderm formation; regulation of transforming growth factor beta receptor signaling pathway; positive regulation of gene expression; immune system development; positive regulation of focal adhesion assembly; liver development; regulation of epithelial cell proliferation; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; negative regulation of mitotic cell cycle; negative regulation of cytosolic calcium ion concentration; canonical Wnt signaling pathway; protein stabilization; transcription, DNA-templated; negative regulation of protein catabolic process; protein deubiquitination; positive regulation of nitric oxide biosynthetic process; negative regulation of lung blood pressure; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of cardiac muscle hypertrophy in response to stress; cellular response to transforming growth factor beta stimulus; cellular response to cytokine stimulus; positive regulation of protein import into nucleus; positive regulation of DNA-binding transcription factor activity; SMAD protein signal transduction; positive regulation of canonical Wnt signaling pathway; SMAD protein complex assembly; adrenal gland development;
	Sources:Amigo / QuickGO
Orthologues
	4088
	17127
	ENSG00000166949
	ENSMUSG00000032402
	P84022
	Q8BUN5
	NM_001145102; NM_001145103; NM_001145104; NM_005902
	NM_016769
	NP_001138574; NP_001138575; NP_001138576; NP_005893
	NP_058049
	Wikidata
Voir/Editer Humain	Voir/Editer Souris