SMAD7

SMAD7
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ
Identifiants
Alias	SMAD7
IDs externes	OMIM: 602932 MGI: 1100518 HomoloGene: 4314 GeneCards: SMAD7
Position du gène (humain)
Chr.	Chromosome 18 humain
Fin	48,950,965 bp
Position du gène (souris)
Chr.	Chromosome 18 (souris)
Fin	75,529,006 bp
Expression génique
	Fortement exprimé dans
	artère poplitée; ; Tibial arteries; ; Veine saphène; ; Descending thoracic aorta; ; auricule de l'oreillette droite; ; aorte ascendante; ; cardiac muscle tissue of right atrium; ; poumon droit; ; artère coronaire gauche; ; artère coronaire droite;
	Fortement exprimé dans
	molaire; ; gastrula; ; left lung lobe; ; antre du pylore; ; crête génitale; ; Caduque basale; ; cumulus cell; ; lumbar subsegment of spinal cord; ; substantia nigra; ; sang;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison ADN; beta-catenin binding; type I transforming growth factor beta receptor binding; collagen binding; I-SMAD binding; activin binding; DNA-binding transcription factor activity; liaison ion métal; liaison protéique; ubiquitin protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; centrosome; transcription regulator complex; membrane plasmique; intracellulaire; nucléoplasme; catenin complex; noyau; fibrillar center; cytosol; complexe macromoléculaire;
Processus biologique	cellular response to transforming growth factor beta stimulus; regulation of ventricular cardiac muscle cell membrane depolarization; pathway-restricted SMAD protein phosphorylation; ureteric bud development; regulation of transcription, DNA-templated; adherens junction assembly; positive regulation of cell-cell adhesion; ventricular septum morphogenesis; regulation of epithelial to mesenchymal transition; negative regulation of peptidyl-threonine phosphorylation; negative regulation of transcription by competitive promoter binding; response to laminar fluid shear stress; protein stabilization; regulation of activin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; BMP signaling pathway; negative regulation of DNA-binding transcription factor activity; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of BMP signaling pathway; ventricular cardiac muscle tissue morphogenesis; negative regulation of protein ubiquitination; negative regulation of cell migration; negative regulation of ubiquitin-protein transferase activity; artery morphogenesis; negative regulation of peptidyl-serine phosphorylation; regulation of cardiac muscle contraction; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of epithelial to mesenchymal transition; positive regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-templated; transforming growth factor beta receptor signaling pathway; protein deubiquitination; negative regulation of T cell cytokine production; negative regulation of T-helper 17 type immune response; negative regulation of T-helper 17 cell differentiation; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologues
	4092
	17131
	ENSG00000101665
	ENSMUSG00000025880
	O15105
	O35253
	NM_005904; NM_001190821; NM_001190822; NM_001190823
	NM_001042660; NM_008543
	NP_001177750; NP_001177751; NP_001177752; NP_005895
	NP_001036125
	Wikidata
Voir/Editer Humain	Voir/Editer Souris