GRB2

GRB2
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW
識別子
記号	GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
外部ID	OMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2
遺伝子の位置 (ヒト)
染色体	17番染色体 (ヒト)
終点	75,405,709 bp
遺伝子の位置 (マウス)
染色体	11番染色体 (マウス)
終点	115,599,423 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• protein domain specific binding; • SH3 domain binding; • プロテインキナーゼ結合; • identical protein binding; • neurotrophin TRKA receptor binding; • protein phosphatase binding; • 血漿タンパク結合; • ephrin receptor binding; • insulin receptor substrate binding; • epidermal growth factor receptor binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphoprotein binding; • 酵素結合; • RNA結合; • non-membrane spanning protein tyrosine kinase activity; • phosphotyrosine residue binding;
細胞の構成要素	• エキソソーム; • 核小体; • 細胞質; • 核質; • COP9シグナロソーム; • ゴルジ体; • 細胞質基質; • 細胞核; • cell-cell junction; • 膜; • Grb2-EGFR complex; • エンドソーム; • vesicle membrane; • 細胞膜; • extrinsic component of cytoplasmic side of plasma membrane; • 高分子複合体; • 細胞内;
生物学的プロセス	• T cell costimulation; • Fc-gamma receptor signaling pathway involved in phagocytosis; • branching involved in labyrinthine layer morphogenesis; • MAPK cascade; • epidermal growth factor receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • insulin receptor signaling pathway; • receptor internalization; • 細胞間シグナル伝達; • 軸索誘導; • positive regulation of reactive oxygen species metabolic process; • cellular response to ionizing radiation; • Fc-epsilon receptor signaling pathway; • viral process; • positive regulation of actin filament polymerization; • signal transduction in response to DNA damage; • negative regulation of epidermal growth factor receptor signaling pathway; • leukocyte migration; • regulation of MAPK cascade; • anatomical structure formation involved in morphogenesis; • 老化; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • protein heterooligomerization; • entry of bacterium into host cell; • membrane organization; • 遊走; • 細胞分化; • peptidyl-tyrosine autophosphorylation; • regulation of cell population proliferation; • 自然免疫; • Ras protein signal transduction; • interleukin-15-mediated signaling pathway; • positive regulation of protein kinase B signaling; • 分子機能制御; • サイトカイン媒介シグナル伝達経路; • positive regulation of Ras protein signal transduction; • neurotrophin TRK receptor signaling pathway;
	出典:Amigo / QuickGO
オルソログ
	2885
	14784
	ENSG00000177885
	ENSMUSG00000059923
	P62993,J3KT38
	Q60631
	NM_203506; NM_002086
	NM_008163; NM_001313936; NM_001313937
	NP_002077; NP_987102
	NP_001300865; NP_001300866; NP_032189
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

GRB2（growth factor receptor bound protein 2）は、シグナル伝達に関与するアダプタータンパク質である。ヒトでは、GRB2タンパク質はGRB2遺伝子によってコードされている^[5]^[6]。

PDBオルソログ検索: RCSB PDBe PDBj

記号GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2

外部IDOMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2

染色体17番染色体 (ヒト)^[1]

概要 PDBに登録されている構造, PDB ...

閉じる

GRB2は上皮成長因子受容体などの受容体に結合するタンパク質で、1つのSH2ドメインと2つのSH3ドメインを有する。2つのSH3ドメインは他のタンパク質のプロリンリッチ領域と直接的に相互作用して複合体形成へ差し向け、SH2ドメインはリン酸化されたチロシンを含む配列に結合する。GRB2遺伝子はCaenorhabditis elegansにおいてシグナル伝達経路に関与しているsem-5遺伝子と類似している。GRB2遺伝子には、異なるアイソフォームをコードする2種類の選択的スプライシングバリアントが発見されている^[7]。

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[6]

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[2]

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[4]

[7]

GRB2

機能

ドメイン

相互作用

出典

関連文献

関連項目

外部リンク

Related Articles

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