8-Phenyltheophylline

ATC code

• None

CAS Number

• 961-45-5 ^N

PubChem CID

• 1922

ChemSpider

• 1846 ^Y

8-Phenyltheophylline

Clinical data
ATC code	None
Identifiers
IUPAC name 8-Phenyl-1,3-dimethyl-7H-purine-2,6-dione
CAS Number	961-45-5 N
PubChem CID	1922
ChemSpider	1846 Y
UNII	E6M543P3BL
ChEMBL	ChEMBL62350 Y
CompTox Dashboard (EPA)	DTXSID90242119
Chemical and physical data
Formula	C13H12N4O2
Molar mass	256.265 g·mol−1
3D model (JSmol)	Interactive image
SMILES Cn3c(=O)c2nc(c1ccccc1)[nH]c2n(C)c3=O
InChI InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15) Y Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

8-Phenyltheophylline (8-phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A₁ and A_2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor.^[1][2][3] It has stimulant effects in animals with similar potency to caffeine.^[4] Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.^[5]