CMX521

Legal status

• US: Investigational drug

CAS Number

• 2077178-99-3 ^Y

PubChem CID

• 126520436

ChemSpider

• 95601723

CMX521

Legal status
Legal status	US: Investigational drug
Identifiers
IUPAC name 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methylpyrrolo[2,3-d]pyrimidine-5-carboxamide
CAS Number	2077178-99-3 Y
PubChem CID	126520436
ChemSpider	95601723
UNII	76US2C2X3F
Chemical and physical data
Formula	C13H17N5O5
Molar mass	323.309 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=NC(=C2C(=CN(C2=N1)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)C(=O)N)N
InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1 Key:PMQFVTNOZQVIOK-HTVVRFAVSA-N

CMX521 is an antiviral drug discovered by Chimerix, which was developed for the treatment of norovirus, though it also shows efficacy against related viral diarrheas such as rotavirus and some sapoviruses, astroviruses and adenoviruses. It is a nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA polymerase.^[1][2][3]