GS-6620

Trade namesGS-6620

Legal status

• US: Investigational New Drug

CAS Number

• 1350735-70-4

PubChem CID

• 58059494

GS-6620

Clinical data
Trade names	GS-6620
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name [(2R,3R,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyl-2-[[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxymethyl]oxolan-3-yl] 2-methylpropanoate
CAS Number	1350735-70-4
PubChem CID	58059494
ChemSpider	31141332
UNII	WD5DUG7X38
ChEMBL	ChEMBL3120792
CompTox Dashboard (EPA)	DTXSID60159240
Chemical and physical data
Formula	C29H37N6O9P
Molar mass	644.622 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H](C(=O)OC(C)C)NP(=O)(OC[C@@H]1[C@H]([C@@]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)(C)O)OC(=O)C(C)C)OC4=CC=CC=C4
InChI InChI=1S/C29H37N6O9P/c1-17(2)26(36)42-24-22(43-29(15-30,28(24,6)38)23-13-12-21-25(31)32-16-33-35(21)23)14-40-45(39,44-20-10-8-7-9-11-20)34-19(5)27(37)41-18(3)4/h7-13,16-19,22,24,38H,14H2,1-6H3,(H,34,39)(H2,31,32,33)/t19-,22+,24+,28+,29-,45?/m0/s1 Key:YAAQYJCOIFNMKX-CVANIGNKSA-N

GS-6620 is an antiviral drug which is a nucleotide analogue. It was developed for the treatment of Hepatitis C but while it showed potent antiviral effects in early testing,^[1][2] it could not be successfully formulated into an oral dosage form due to low and variable absorption in the intestines which made blood levels unpredictable.^[3][4] It has however continued to be researched as a potential treatment for other viral diseases such as Ebola virus disease.^[5][6]