Indatuximab ravtansine
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| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Chimeric (mouse/human) |
| Target | SDC1 |
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Indatuximab ravtansine (BT062) is an immunomodulator and antineoplastic antibody-drug conjugate.
It is the anti-CD138 chimerized MAb (nBT062)[1] linked to the maytansinoid DM4.[1]
It is being investigated as part of a treatment for multiple myeloma.[1]
Multiple Myeloma
Preliminary data has been reported in 2013 from an early stage clinical trial in combination with Lenalidomide and Dexamethasone.[1] Follow up data reported "encouraging efficacy" in December 2014.[2]
Other
As of December 2014[update], it is in clinical trials for triple negative metastatic breast cancer and metastatic urinary bladder cancer.[2]