LTBP1 (gene)

PDBOrtholog search: PDBe RCSB

AliasesLTBP1, latent transforming growth factor beta binding protein 1

External IDsOMIM: 150390; MGI: 109151; HomoloGene: 522; GeneCards: LTBP1; OMA:LTBP1 - orthologs

Chr.Chromosome 2 (human)^[1]

LTBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KSQ
Identifiers
Aliases	LTBP1, latent transforming growth factor beta binding protein 1
External IDs	OMIM: 150390; MGI: 109151; HomoloGene: 522; GeneCards: LTBP1; OMA:LTBP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.3 Start 32,946,953 bp[1] End 33,399,509 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2 Start 75,312,563 bp[2] End 75,699,507 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery Descending thoracic aorta ascending aorta saphenous vein stromal cell of endometrium urethra popliteal artery tibial arteries ventricular zone left coronary artery Top expressed in ascending aorta cumulus cell tunica media of zone of aorta aortic valve ciliary body umbilical cord efferent ductule atrium blood human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calcium ion binding transforming growth factor beta-activated receptor activity growth factor binding microfibril binding transforming growth factor beta binding extracellular matrix structural constituent Cellular component extracellular matrix microfibril extracellular space endoplasmic reticulum lumen extracellular region protein-containing complex collagen-containing extracellular matrix Biological process ventricular septum development sequestering of TGFbeta in extracellular matrix coronary vasculature development aorta development transmembrane receptor protein serine/threonine kinase signaling pathway post-translational protein modification regulation of transforming growth factor beta activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4052 268977 Ensembl ENSG00000049323 ENSMUSG00000001870 UniProt Q14766 Q8CG19 RefSeq (mRNA) NM_000627 NM_001166264 NM_001166265 NM_001166266 NM_206943 NM_019919 NM_206958 NM_001331233 NM_001331234 NM_001331235 NM_001331236 NM_001331237 RefSeq (protein) NP_000618 NP_001159736 NP_001159737 NP_001159738 NP_996826 NP_001318162 NP_001318163 NP_001318164 NP_001318165 NP_001318166 NP_064303 NP_996841 Location (UCSC) Chr 2: 32.95 – 33.4 Mb Chr 17: 75.31 – 75.7 Mb PubMed search [3] [4]
Wikidata
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Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.^[5][6][7]

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]