ABCA1

ABCA1
Identifiants
Alias	ABCA1
IDs externes	OMIM: 600046 MGI: 99607 HomoloGene: 21130 GeneCards: ABCA1
Position du gène (humain)
Chr.	Chromosome 9 humain
Fin	104,928,155 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	53,159,895 bp
Expression génique
	Fortement exprimé dans
	skin of hip; ; left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; skin of thigh; ; right adrenal cortex; ; epithelium of colon; ; stromal cell of endometrium; ; lobe inférieur du poumon; ; foie;
	Fortement exprimé dans
	stroma of bone marrow; ; subcutaneous adipose tissue; ; skin of external ear; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; transitional epithelium of urinary bladder; ; gastrula; ; Caduque basale; ; left lobe of liver; ; corps ciliaire;
	Plus de données d'expression de référence
	; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	ATPase-coupled transmembrane transporter activity; apolipoprotein binding; liaison nucléotide; liaison d'ATPase; apolipoprotein A-I receptor activity; anion transmembrane transporter activity; phospholipid transporter activity; cholesterol binding; small GTPase binding; liaison protéique; syntaxin binding; signaling receptor binding; phospholipid binding; liaison ATP; cholesterol transfer activity; phosphatidylserine floppase activity; activité ATPase; phosphatidylcholine floppase activity; apolipoprotein A-I binding; high-density lipoprotein particle binding; lipid transporter activity;
Composant cellulaire	integral component of membrane; appareil de Golgi; membrane; membrane plasmique; endocytic vesicle; integral component of plasma membrane; surface cellulaire; phagocytic vesicle; high-density lipoprotein particle; perinuclear region of cytoplasm; radeau lipidique; external side of plasma membrane; membrane du réticulum endoplasmique; intracellular membrane-bounded organelle; endosome;
Processus biologique	G protein-coupled receptor signaling pathway; cellular response to retinoic acid; phospholipid homeostasis; processus métabolique stéroidique; platelet dense granule organization; regulation of Cdc42 protein signal transduction; response to nutrient; processus métabolique lipidique; phospholipid efflux; phospholipid transport; cholesterol transport; response to laminar fluid shear stress; peptide secretion; cholesterol metabolic process; cellular response to cholesterol; negative regulation of cholesterol storage; endosomal transport; phagocytosis, engulfment; anion transmembrane transport; intracellular cholesterol transport; cholesterol efflux; protein lipidation; lipoprotein biosynthetic process; lysosome organization; cellular response to lipopolysaccharide; negative regulation of macrophage derived foam cell differentiation; reverse cholesterol transport; apolipoprotein A-I-mediated signaling pathway; positive regulation of cholesterol efflux; phospholipid translocation; regulation of high-density lipoprotein particle assembly; transport transmembranaire; cholesterol homeostasis; regulation of lipid metabolic process; high-density lipoprotein particle assembly; lipoprotein metabolic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to low-density lipoprotein particle stimulus; lipid transport; positive regulation of high-density lipoprotein particle assembly;
	Sources:Amigo / QuickGO
Orthologues
	19
	11303
	ENSG00000165029
	ENSMUSG00000015243
	O95477
	P41233
	NM_005502
	NM_013454
	NP_005493
	NP_038482
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

AliasABCA1

IDs externesOMIM: 600046 MGI: 99607 HomoloGene: 21130 GeneCards: ABCA1

Chr.Chromosome 9 humain^[1]

Fin104,928,155 bp^[1]

L'ABCA1 (pour « ATP-binding cassette A1 ») est une protéine appartenant à la famille des transporteurs ABC et intervenant dans le transport du cholestérol. Son gène est le ABCA1 situé sur le chromosome 9 humain.

[1]

[2]

[3]

[4]

v · m Transporteurs ABC
Gènes	ABCA1 ABCA2 ABCA3 ABCA4 ABCA5 ABCA6 ABCA7 ABCA8 ABCA9 ABCA10 ABCA11 ABCA13 ABCB1 ABCB2 ABCB3 ABCB4 ABCB5 ABCB6 ABCB7 ABCB8 ABCB9 ABCB10 ABCB11 ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC7 ABCC8 ABCC9 ABCC10 ABCC11 ABCC12 ABCD1 ABCD2 ABCD3 ABCD4 ABCE1 ABCF1 ABCF2 ABCF3 ABCG1 ABCG2 ABCG4 ABCG5 ABCG6
Protéines	ABCA1
Maladies liées	Immunodéficience Maladie de Tangier Mucoviscidose Pseudoxanthome élastique Sitostérolémie Syndrome de Dubin-Johnson

ABCA1

En médecine

Notes et références

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