GNAS

GNAS
Identifiants
Alias	GNAS
IDs externes	OMIM: 139320 MGI: 95777 HomoloGene: 55534 GeneCards: GNAS
Position du gène (humain)
Chr.	Chromosome 20 humain
Fin	58,911,192 bp
Position du gène (souris)
Chr.	Chromosome 2 (souris)
Fin	174,188,537 bp
Expression génique
	Fortement exprimé dans
	cellule bêta; ; gyrus postcentral; ; Brodmann area 46; ; hypophyse; ; lateral nuclear group of thalamus; ; anté-hypophyse; ; Brodmann area 10; ; cortex entorhinal; ; gyrus frontal supérieur; ; frontal pole;
	Fortement exprimé dans
	ganglion cervical supérieur; ; cortex entorhinal; ; dorsomedial hypothalamic nucleus; ; Cortex périrhinal; ; hypophyse; ; CA3 field; ; fœtus humain; ; central gray substance of midbrain; ; éminence médiane; ; derme;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	fonction moléculaire; liaison nucléotide; G-protein beta/gamma-subunit complex binding; GTP binding; signal transducer activity; liaison ion métal; liaison protéique; GTPase activity; guanyl nucleotide binding; adenylate cyclase activator activity; insulin-like growth factor receptor binding; mu-type opioid receptor binding; corticotropin-releasing hormone receptor 1 binding; beta-2 adrenergic receptor binding; ionotropic glutamate receptor binding; D1 dopamine receptor binding; G protein-coupled receptor binding;
Composant cellulaire	cytoplasme; perinuclear region of cytoplasm; région extracellulaire; vésicule de transport; vésicule cytoplasmique; noyau; cytosol; trans-Golgi network membrane; membrane; membrane plasmique; heterotrimeric G-protein complex; intrinsic component of membrane; exosome; ruffle; prolongement cellulaire; dendrite; apical plasma membrane;
Processus biologique	gestation; negative regulation of multicellular organism growth; response to parathyroid hormone; protein secretion; positive regulation of cold-induced thermogenesis; hair follicle placode formation; cellular response to catecholamine stimulus; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cognition; regulation of insulin secretion; cellular response to glucagon stimulus; intracellular transport; positive regulation of cAMP-mediated signaling; activation of adenylate cyclase activity; cellular response to prostaglandin E stimulus; adenylate cyclase-activating adrenergic receptor signaling pathway; sensory perception of smell; positive regulation of GTPase activity; developmental growth; renal water homeostasis; développement osseux; Agrégation plaquettaire; transduction de signal; G protein-coupled receptor signaling pathway; regulation of signal transduction; skeletal system development; gène soumis à empreinte; multicellular organism growth; positive regulation of osteoclast differentiation; ossification endochondrale; regulation of parathyroid hormone secretion; développement postembryonnaire; post-embryonic body morphogenesis; méthylation de l'ADN; cartilage development; positive regulation of osteoblast differentiation; tissue homeostasis; sensory perception of chemical stimulus; embryonic cranial skeleton morphogenesis; energy reserve metabolic process; skin development; embryonic hindlimb morphogenesis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologues
	2778
	14683
	ENSG00000087460
	ENSMUSG00000027523
	O95467; P63092; P84996; Q5JWF2
	P63094; Q6R0H7; Q9Z0F1; Q6R0H6
NM_000516; NM_001077488; NM_001077489; NM_001077490; NM_001309840;
	NM_001309842; NM_001309861; NM_001309883; NM_016592; NM_080425; NM_080426
NM_001077507; NM_001077510; NM_010309; NM_010310; NM_019690;
	NM_022000; NM_201616; NM_201617; NM_201618; NM_001310083; NM_001310085; NM_001364030
NP_000507; NP_001070956; NP_001070957; NP_001070958; NP_001296769;
	NP_001296771; NP_001296790; NP_001296812; NP_057676; NP_536350; NP_536351; NP_000507.1; NP_001070956.1; NP_001070957.1; NP_001070958.1; NP_001296769.1; NP_536350.2; NP_536351.1; NP_001070958.1; NP_001296812.1; NP_001296812.1; NP_536350.2
NP_001070975; NP_001070978; NP_001297012; NP_001297014; NP_034439;
	NP_062664; NP_068840; NP_963910; NP_963911; NP_963912; NP_001350959; NP_001070975.1; NP_001297014.1; NP_034439.2; NP_963911.1; NP_062664.2; NP_068840.2; NP_001070975.1; NP_001297014.1; NP_963911.1; NP_963912.1
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

AliasGNAS

IDs externesOMIM: 139320 MGI: 95777 HomoloGene: 55534 GeneCards: GNAS

Chr.Chromosome 20 humain^[1]

Fin58,911,192 bp^[1]

Le GNAS (pour Guanine Nucleotide binding protein, Alpha Stimulating activity polypeptide, ou polypeptide se fixant sur la guanine avec effet de stimulation alpha), est une sous-unité constitutive de la Protéine G hétérotrimérique. Son gène est GNAS situé sur le chromosome 20 humain

[1]

[2]

[3]

[4]

v · m Chromosome 20 humain
Gènes	GNAS CHRNA4 ADA DNMT3B COL9A3 COL20A1
Maladies liées	Trisomie 20 Maladie de Hirschsprung Dysplasie fibreuse des os Syndrome de McCune–Albright Épilepsie frontale à crises nocturnes Déficit immunitaire combiné sévère par déficit en adénosine-désaminase ICF syndrome Syndrome d'Alagille Syndrome de Bardet-Biedl Syndrome de McKusick Kaufman Neurodégénerescence associée à la pantothénate-kinase Galactosialidose

GNAS

Notes et références

Liens externes

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