LYN (protéine)

LYN
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1W1F, 1WA7, 3A4O
Identifiants
Alias	LYN
IDs externes	OMIM: 165120 MGI: 96892 HomoloGene: 55649 GeneCards: LYN
Position du gène (humain)
Chr.	Chromosome 8 humain
Fin	56,014,169 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	3,813,122 bp
Expression génique
	Fortement exprimé dans
	monocyte; ; sang; ; palpebral conjunctiva; ; moelle osseuse; ; nasal epithelium; ; cellule de la moelle osseuse; ; appendice iléo-cæcal; ; ligament alvéolo-dentaire; ; granulocyte; ; os spongieux;
	Fortement exprimé dans
	stroma of bone marrow; ; granulocyte; ; sang; ; ganglion mésentérique; ; Vasculature of brain; ; rate; ; tibiofemoral joint; ; lobe pulmonaire droit; ; poumon gauche; ; left lung lobe;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	transmembrane transporter binding; SH3 domain binding; liaison de complexe macromoléculaire; activité kinase; gamma-tubulin binding; signaling receptor binding; liaison ATP; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; liaison enzymatique; activité de transférase; platelet-derived growth factor receptor binding; integrin binding; liaison protéique; glycosphingolipid binding; protein tyrosine kinase activity; liaison nucléotide; phosphoprotein binding; ubiquitin protein ligase binding; ephrin receptor binding; phosphorylation-dependent protein binding;
Composant cellulaire	cytoplasme; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; mitochondrial intermembrane space; perinuclear region of cytoplasm; noyau; mitochondrial membranes; radeau lipidique; exosome; appareil de Golgi; membrane plasmique; postsynaptic density; mast cell granule; integrin alpha2-beta1 complex; crête mitochondriale; intracellular membrane-bounded organelle; glutamatergic synapse; postsynaptic specialization, intracellular component;
Processus biologique	regulation of protein phosphorylation; cellular response to extracellular stimulus; cellular response to retinoic acid; positive regulation of B cell receptor signaling pathway; tolerance induction to self antigen; regulation of mast cell activation; regulation of cell adhesion mediated by integrin; cellular response to heat; response to amino acid; hématopoïèse; adaptive immune response; regulation of erythrocyte differentiation; cellular response to DNA damage stimulus; positive regulation of Fc receptor mediated stimulatory signaling pathway; platelet activation; Fc-epsilon receptor signaling pathway; phosphorylation des protéines; regulation of B cell apoptotic process; positive regulation of dendritic cell apoptotic process; positive regulation of glial cell proliferation; response to carbohydrate; regulation of platelet aggregation; negative regulation of cell population proliferation; B cell receptor signaling pathway; negative regulation of myeloid leukocyte differentiation; dendritic cell differentiation; Fc receptor mediated inhibitory signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of B cell receptor signaling pathway; stimulatory C-type lectin receptor signaling pathway; response to sterol depletion; positive regulation of stress-activated protein kinase signaling cascade; regulation of cytokine production; response to insulin; positive regulation of mast cell proliferation; negative regulation of MAP kinase activity; regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-tyrosine phosphorylation; erythrocyte differentiation; protein autophosphorylation; oligodendrocyte development; regulation of mast cell degranulation; positive regulation of phosphorylation; viral process; réponse à une substance toxique; negative regulation of protein phosphorylation; Fc receptor mediated stimulatory signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; phosphorylation; processus du système immunitaire; regulation of release of sequestered calcium ion into cytosol; positive regulation of tyrosine phosphorylation of STAT protein; B cell homeostasis; immune response-regulating cell surface receptor signaling pathway; response to axon injury; negative regulation of mast cell proliferation; regulation of inflammatory response; peptidyl-tyrosine autophosphorylation; response to hormone; regulation of monocyte chemotaxis; leukocyte migration; lipopolysaccharide-mediated signaling pathway; histamine secretion by mast cell; intracellular signal transduction; response to organic cyclic compound; negative regulation of intracellular signal transduction; positive regulation of cell migration; ephrin receptor signaling pathway; negative regulation of toll-like receptor 2 signaling pathway; T cell costimulation; response to peptide hormone; platelet degranulation; coagulation sanguine; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of oligodendrocyte progenitor proliferation; negative regulation of immune response; positive regulation of cell population proliferation; positive regulation of neuron projection development; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine phosphorylation; negative regulation of B cell proliferation; negative regulation of toll-like receptor 4 signaling pathway; transduction de signal; système immunitaire inné; neuron projection development; central nervous system development; réponse inflammatoire; positive regulation of protein phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; différenciation cellulaire; positive regulation of Ras protein signal transduction; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;
	Sources:Amigo / QuickGO
Orthologues
	4067
	17096
	ENSG00000254087
	ENSMUSG00000042228
	P07948
	P25911
	NM_001111097; NM_002350
	NM_001111096; NM_010747
	NP_001104567; NP_002341
	NP_001104566; NP_034877
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasLYN

IDs externesOMIM: 165120 MGI: 96892 HomoloGene: 55649 GeneCards: LYN

Chr.Chromosome 8 humain^[1]

LYN est une protéine de type tyrosine kinase dont le gène est le LYN situé sur le chromosome 8 humain.

[1]

[2]

[3]

[4]

v · m Chromosome 8 humain
Gènes	ASAH CHD7 COH1 COL14A1 COL22A1 CYP11B1 ESCO2 EXT1 EYA1 GDAP1 LPL NDRG1 NEFL POP1 RECQL4 TRPS1 TTPA ZFPM2
Protéines	Géranylgéranyltransférase de type 1 Glutathion-réductase Lipoprotéine-lipase Protéine-phosphatase 2 Thyroglobuline
Maladies liées	Achromatopsie Amélogenèse imparfaite Ataxie avec déficit isolé en vitamine E Déficit familial en lipoprotéine-lipase Dysplasie anauxétique Hyperplasie congénitale des surrénales Maladie de Charcot-Marie-Tooth Maladie de Farber Syndrome CHARGE Syndrome branchio-oto-rénal Syndrome de Cohen Syndrome de Fryns Syndrome de Jackson-Weiss Syndrome de Lenz-Majewski Syndrome de Roberts Syndrome de Rothmund-Thomson Syndrome tricho-rhino-phalangien type 1 type 2 Tétralogie de Fallot

LYN (protéine)

Cible thérapeutique

Notes et références

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